ArticleDevelopmental biology2011
Evolutionary bioscience as regulatory systems biology.
Article in Developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- Governing principles of transcriptional logic out of equilibrium.Biophysical journal · 2024Article
- Spatially and Temporally Distributed Complexity-A Refreshed Framework for the Study of GRN Evolution.Cells · 2022Article
- Combinatorial Gene Regulation through Kinetic Control of the Transcription Cycle.Cell systems · 2017Article
- Conserved Noncoding Elements in the Most Distant Genera of Cephalochordates: The Goldilocks Principle.Genome biology and evolution · 2016Article
- Extended evolution: A conceptual framework for integrating regulatory networks and niche construction.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2015Article
- Developmental control of transcriptional and proliferative potency during the evolutionary emergence of animals.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Divergence in a master variator generates distinct phenotypes and transcriptional responses.Genes & development · 2014Article
- Article
- PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF.PLoS genetics · 2014Article
- The mystery of extreme non-coding conservation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- The Acoela: on their kind and kinships, especially with nemertodermatids and xenoturbellids (Bilateria incertae sedis).Organisms, diversity & evolution · 2013Article
- Experimental approaches for gene regulatory network construction: the chick as a model system.Genesis (New York, N.Y. : 2000) · 2013Review
- Actomyosin-based self-organization of cell internalization during C. elegans gastrulation.BMC biology · 2012Article
- Initial deployment of the cardiogenic gene regulatory network in the basal chordate, Ciona intestinalis.Developmental biology · 2012Article
- The Comet Cometh: Evolving Developmental Systems.Biological theoryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
At present several entirely different explanatory approaches compete to illuminate the mechanisms by which animal body plans have evolved. Their respective relevance is briefly considered here in the light of modern knowledge of genomes and the regulatory processes by which development is controlled. Just as development is a system property of the regulatory genome, causal explanation of evolutionary change in developmental process must be considered at a system level. Here I enumerate some mechanistic consequences that follow from the conclusion that evolution of the body plan has occurred by alteration of the structure of developmental gene regulatory networks. The hierarchy and multiple additional design features of these networks act to produce Boolean regulatory state specification functions at upstream phases of development of the body plan. These are created by the logic outputs of network subcircuits, and in modern animals these outputs are impervious to continuous adaptive variation unlike genes operating more peripherally in the network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.