ArticleBiophysical journal2011
Interleaflet coupling and domain registry in phase-separated lipid bilayers.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.Biophysical journal · 2026Article
- Quantifying interleaflet coupling of phase behavior and observing anti-registered phases in asymmetric lipid bilayers.bioRxiv : the preprint server for biology · 2026Article
- Asymmetry and heterogeneity in the plasma membrane.Biophysical journal · 2026Article
- Measuring the Transmembrane Registration of Lipid Domains in Droplet Interface Bilayers through Tensiometry.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Seeing the Membrane from Both Sides Now: Lipid Asymmetry and Its Strange Consequences.Cold Spring Harbor perspectives in biology · 2023Review
- A Theoretical Basis for Nanodomains.The Journal of membrane biology · 2022Review
- Sensing a little friction.Biophysical journal · 2022Article
- Systematic measurements of interleaflet friction in supported bilayers.Biophysical journal · 2022Article
- Investigation of the domain line tension in asymmetric vesicles prepared via hemifusion.Biochimica et biophysica acta. Biomembranes · 2021Article
- Model Plasma Membrane Exhibits a Microemulsion in Both Leaves Providing a Foundation for "Rafts".Biophysical journal · 2020Article
- Role of Transmembrane Proteins for Phase Separation and Domain Registration in Asymmetric Lipid Bilayers.Biomolecules · 2019Article
- Effects of Passive Phospholipid Flip-Flop and Asymmetric External Fields on Bilayer Phase Equilibria.Biophysical journal · 2018Article
- Accurate In Silico Modeling of Asymmetric Bilayers Based on Biophysical Principles.Biophysical journal · 2018Article
- Computational Lipidomics of the Neuronal Plasma Membrane.Biophysical journal · 2017Article
- Lipid Domain Co-localization Induced by Membrane Undulations.Biophysical journal · 2017Article
- Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The aliphatic chain of cholesterol modulates bilayer interleaflet coupling and domain registration.FEBS letters · 2016Article
- Roles of Interleaflet Coupling and Hydrophobic Mismatch in Lipid Membrane Phase-Separation Kinetics.Journal of the American Chemical Society · 2016Article
- Galimzyanov et al. Reply.Physical review letters · 2016Article
- Interleaflet mixing and coupling in liquid-disordered phospholipid bilayers.Biochimica et biophysica acta · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
There is clear evidence of an interleaflet coupling in model lipid/cholesterol membranes exhibiting liquid-liquid phase separation. The strength of this coupling is quantified by the mismatch free energy, γ. We calculate it using a molecular mean-field model of a phase-separated lipid/cholesterol bilayer and obtain values that increase as the concentration of saturated lipids in the coexisting phases is increased. These values lie in the range 0.01-0.03 k(B)T/nm(2). We clarify the relationship between the interleaflet coupling and the extent of interleaflet alignment of liquid domains by analyzing a statistical mechanical model of coupled fluctuating domain interfaces. The model is solved exactly using the correspondence between statistical mechanics and quantum mechanics, yielding an expression for the characteristic size of fluctuations out of domain registry. This length scale depends only weakly on the strength of the interleaflet coupling and inevitably is only of the order of nanometers, which explains the experimental result that fluctuations out of domain registry have not been observed by optical microscopy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.