ArticleBiophysical journal2011
A theory for the proton transport of the influenza virus M2 protein: extensive test against conductance data.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior.Journal of the American Chemical Society · 2022Article
- Viroporins in the Influenza Virus.Cells · 2019Review
- Activation pH and Gating Dynamics of Influenza A M2 Proton Channel Revealed by Single-Molecule Spectroscopy.Angewandte Chemie (International ed. in English) · 2017Article
- Acid activation mechanism of the influenza A M2 proton channel.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel.Physical chemistry chemical physics : PCCP · 2016Article
- Ion efflux and influenza infection trigger NLRP3 inflammasome signaling in human dendritic cells.Journal of leukocyte biology · 2016Article
- Dynamic Short Hydrogen Bonds in Histidine Tetrad of Full-Length M2 Proton Channel Reveal Tetrameric Structural Heterogeneity and Functional Mechanism.Structure (London, England : 1993) · 2015Article
- Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors.The journal of physical chemistry. B · 2015Article
- Multiscale simulation reveals a multifaceted mechanism of proton permeation through the influenza A M2 proton channel.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel.The Journal of chemical physics · 2014Article
- Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein.Biochimica et biophysica acta · 2014Article
- Theoretical frameworks for multiscale modeling and simulation.Current opinion in structural biology · 2014Review
- Philosophy of voltage-gated proton channels.Journal of the Royal Society, Interface · 2014Review
- Article
- Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus.Structure (London, England : 1993) · 2013Article
- Article
- Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family.Physiological reviews · 2013Review
- Modeling the membrane environment has implications for membrane protein structure and function: influenza A M2 protein.Protein science : a publication of the Protein Society · 2013Review
- M2 proton channel structural validation from full-length protein samples in synthetic bilayers and E. coli membranes.Angewandte Chemie (International ed. in English) · 2012Article
- M2 protein from influenza A: from multiple structures to biophysical and functional insights.Current opinion in virology · 2012Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
A theory for calculating the proton flux through the influenza virus M2 channel is tested here against an extensive set of conductance data. The flux is determined by the rate constants for binding to the His(37) tetrad from the two sides of the membrane and the corresponding unbinding rate constants. The rate constants are calculated by explicitly treating the structure and dynamics of the protein. Important features revealed by previous studies, such as a gating role for Val(27) at the entrance to the channel pore, and channel activation by viral exterior pH, are incorporated in this theory. This study demonstrates that the conductance function of the M2 proton channel can now be quantitatively rationalized by the structure and dynamics of the protein.
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