ArticleBiophysical journal2011
A matter of life or death: modeling DNA damage and repair in bacteria.
Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Host methylglyoxal activates theProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Simplified modeling of E. coli mortality after genome damage induced by UV-C light exposure.Scientific reports · 2020Article
- A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration.Biophysical journal · 2016Article
- Integrated stress response of Escherichia coli to methylglyoxal: transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I.Molecular microbiology · 2013Article
- Single-molecule DNA repair in live bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- In vivo and in silico analysis of PCNA ubiquitylation in the activation of the Post Replication Repair pathway in S. cerevisiae.BMC systems biology · 2013Article
- Optimality in DNA repair.Journal of theoretical biology · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
DNA damage is a hazard all cells must face, and evolution has created a number of mechanisms to repair damaged bases in the chromosome. Paradoxically, many of these repair mechanisms can create double-strand breaks in the DNA molecule which are fatal to the cell. This indicates that the connection between DNA repair and death is far from straightforward, and suggests that the repair mechanisms can be a double-edged sword. In this report, we formulate a mathematical model of the dynamics of DNA damage and repair, and we obtain analytical expressions for the death rate. We predict a counterintuitive relationship between survival and repair. We can discriminate between two phases: below a critical threshold in the number of repair enzymes, the half-life decreases with the number of repair enzymes, but becomes independent of the number of repair enzymes above the threshold. We are able to predict quantitatively the dependence of the death rate on the damage rate and other relevant parameters. We verify our analytical results by simulating the stochastic dynamics of DNA damage and repair. Finally, we also perform an experiment with Escherichia coli cells to test one of the predictions of our model.
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Registered trials
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