ArticleBMC medical genetics2011
Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
Article in BMC medical genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
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- Glutathione S-transferase, catalase, and mitochondrial superoxide dismutase gene polymorphisms modulate redox potential in systemic lupus erythematosus patients from Manaus, Amazonas, Brazil.Clinical rheumatology · 2021Article
- Antioxidant-Rich Diet,Frontiers in oncology · 2020Article
- Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.Frontiers in genetics · 2019Article
- Lack of association between glutathione s-transferase mu 1 (Journal of exercise rehabilitation · 2017Article
- Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus.Italian journal of pediatrics · 2016Article
- The Association between Gene-Environment Interactions and Diseases Involving the Human GST Superfamily with SNP Variants.International journal of environmental research and public health · 2016Review
- Factors associated with asthma among under-fives in Mulago hospital, Kampala Uganda: a cross sectional study.BMC pediatrics · 2013Article
- Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study.The Lancet. Respiratory medicine · 2013Article
- Racial differences in the association of CD14 polymorphisms with serum total IgE levels and allergen skin test reactivity.Journal of asthma and allergy · 2013Article
- Role of GSTM1 in resistance to lung inflammation.Free radical biology & medicine · 2012Review
- Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities.Antioxidants & redox signaling · 2012Review
- African American Patients with Chronic Rhinosinusitis Have a Distinct Phenotype of Polyposis Associated with Increased Asthma Hospitalization.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAsthma and allergy represent complex phenotypes, which disproportionately burden ethnic minorities in the United States. Strong evidence for genomic factors predisposing subjects to asthma/allergy is available. However, methods to utilize this information to identify high risk groups are variable and replication of genetic associations in African Americans is warranted.
methodsWe evaluated 41 single nucleotide polymorphisms (SNP) and a deletion corresponding to 11 genes demonstrating association with asthma in the literature, for association with asthma, atopy, testing positive for food allergens, eosinophilia, and total serum IgE among 141 African American children living in Detroit, Michigan. Independent SNP and haplotype associations were investigated for association with each trait, and subsequently assessed in concert using a genetic risk score (GRS).
resultsStatistically significant associations with asthma were observed for SNPs in GSTM1, MS4A2, and GSTP1 genes, after correction for multiple testing. Chromosome 11 haplotype CTACGAGGCC (corresponding to MS4A2 rs574700, rs1441586, rs556917, rs502581, rs502419 and GSTP1 rs6591256, rs17593068, rs1695, rs1871042, rs947895) was associated with a nearly five-fold increase in the odds of asthma (Odds Ratio (OR) = 4.8, p = 0.007). The GRS was significantly associated with a higher odds of asthma (OR = 1.61, 95% Confidence Interval = 1.21, 2.13; p = 0.001).
conclusionsVariation in genes associated with asthma in predominantly non-African ethnic groups contributed to increased odds of asthma in this African American study population. Evaluating all significant variants in concert helped to identify the highest risk subset of this group.
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