Evidence map›Paper›PMID 21320255›Full record

ArticleBipolar disorders2011

Suicidality in pediatric bipolar disorder: predictor or outcome of family processes and mixed mood presentation?

Guillermo Pérez Algorta, Eric A Youngstrom, Thomas W Frazier, Andrew J Freeman, Jennifer Kogos Youngstrom, Robert L Findling

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Bipolar disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Guillermo Pérez AlgortaCentro Clinico del Sur, Montevideo, Uruguay.
Eric A Youngstrom
Thomas W Frazier
Andrew J Freeman
Jennifer Kogos Youngstrom
Robert L Findling
University of North Carolina at Chapel Hill · USCase Western Reserve University · USCleveland Clinic · US

Funding

Assessment of Juvenille Bipolar Spectrum DisordersR01MH066647 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YOUNGSTROM, ERIC · 2003 to 2007
$2.4M
NIMH NIH HHS R01 MH066647
6 · The paper itself

Abstract

objectivePediatric bipolar disorder (PBD) involves a potent combination of mood dysregulation and interpersonal processes, placing these youth at significantly greater risk of suicide. We examined the relationship between suicidal behavior, mood symptom presentation, family functioning, and quality of life (QoL) in youth with PBD.

methodsParticipants were 138 youths aged 5-18 years presenting to outpatient clinics with DSM-IV diagnoses of bipolar I disorder (n=27), bipolar II disorder (n=18), cyclothymic disorder (n=48), and bipolar disorder not otherwise specified (n=45).

resultsTwenty PBD patients had lifetime suicide attempts, 63 had past or current suicide ideation, and 55 were free of suicide ideation and attempts. Attempters were older than nonattempters. Suicide ideation and attempts were linked to higher depressive symptoms, and rates were even higher in youths meeting criteria for the mixed specifier proposed for DSM-5. Both suicide ideation and attempts were associated with lower youth QoL and poorer family functioning. Parent effects (with suicidality treated as outcome) and child effects (where suicide was the predictor of poor family functioning) showed equally strong evidence in regression models, even after adjusting for demographics.

conclusionsThese findings underscore the strong association between mixed features and suicidality in PBD, as well as the association between QoL, family functioning, and suicidality. It is possible that youths are not just a passive recipient of family processes, and their illness may play an active role in disrupting family functioning. Replication with longitudinal data and qualitative methods should investigate both child and parent effect models.

Indexed as

AffectFamilyAdolescentAge DistributionBipolar DisorderChildChild, PreschoolCross-Sectional StudiesDepressionFamily RelationsFemaleHumansMalePredictive Value of TestsQuality of LifeRisk Factors

Identifiers

PMID21320255
PMCPMC3076793
OpenAlexW2114535523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.