ArticleYonsei medical journal2011
Utility of procalcitonin as an early diagnostic marker of bacteremia in patients with acute fever.
Article in Yonsei medical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.
- Clinical and Cost-Effectiveness of Procalcitonin Test for Prodromal Meningococcal Disease-A Meta-Analysis.PloS one · 2015Pooled it
- Performance of procalcitonin point-of-care tests in predicting bacterial causes of acute febrile illness in Northwest Ethiopia.BMC infectious diseases · 2025Article
- Current Status of Antibiotic Stewardship and the Role of Biomarkers in Antibiotic Stewardship Programs.Infection & chemotherapy · 2022Review
- A Clinical Diagnostic Study: Fibulin-2 is a Novel Promising Biomarker for Predicting Infection.Infectious diseases and therapy · 2022Article
- Bacteremia detection from complete blood count and differential leukocyte count with machine learning: complementary and competitive with C-reactive protein and procalcitonin tests.BMC infectious diseases · 2022Article
- SerumJournal of clinical medicine · 2021Article
- Serum procalcitonin as a biomarker of bloodstream infection & focal bacterial infection in febrile patients.The Indian journal of medical research · 2020Article
- A semi-quantitative rapid multi-range gradient lateral flow immunoassay for procalcitonin.Mikrochimica acta · 2019Article
- Serum Procalcitonin Level as a Predictor of Bacterial Infection in Patients with COPD Exacerbation.Tanaffos · 2019Article
- High Serum Procalcitonin Concentrations in Patients With Hemorrhagic Fever With Renal Syndrome Caused by Hantaan Virus.Frontiers in cellular and infection microbiology · 2018Article
- QUAD fever: beware of non-infectious fever in high spinal cord injuries.BMJ case reports · 2017Article
- Article
- Article
- Observational
- Levels of serum procalcitonin and C-reactive protein for evaluating pulmonary bacterial infection in patients with lupus erythematosus.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- Diagnostic value of sTREM-1 and procalcitonin levels in the early diagnosis of sepsis.Northern clinics of Istanbul · 2016Article
- Can We Reduce Negative Blood Cultures With Clinical Scores and Blood Markers? Results From an Observational Cohort Study.Medicine · 2015Observational
- Evaluation of procalcitonin, C-reactive protein, interleukin-6 & serum amyloid A as diagnostic biomarkers of bacterial infection in febrile patients.The Indian journal of medical research · 2015Article
- Biomarkers for the diagnosis of bacterial infections: in pursuit of the 'Holy Grail'.The Indian journal of medical research · 2015Article
- Procalcitonin and C-reactive protein in differantiating to contamination from bacteremia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeProcalcitonin (PCT) is a current, frequently used marker for severe bacterial infection. The aim of this study was to assess the ability of PCT levels to differentiate bacteremic from nonbacteremic patients with fever. We assessed whether PCT level could be used to accurately rule out a diagnosis of bacteremia. MATERIALS AND
methodsSerum samples and blood culture were obtained from patients with fever between August 2008 and April 2009. PCT was analyzed using a VIDAS® B.R.A.H.M.S PCT assay. We reviewed the final diagnosis and patient histories, including clinical presentation and antibiotic treatment.
resultsA total of 300 patients with fevers were enrolled in this study: 58 with bacteremia (positive blood culture) (group I); 137 with local infection (group II); 90 with other diseases (group III); and 15 with fevers of unknown origin (group IV). PCT levels were significantly higher in patients with bacteremia than in those with non-bacteremia (11.9 ± 25.1 and 2.5 ± 14.7 ng/mL, respectively, p < 0.001). The sensitivity and specificity were 74.2% and 70.1%, respectively, at a cut-off value of 0.5 ng/mL. A serum PCT level of < 0.4 ng/mL accurately rules out diagnosis of bacteremia.
conclusionIn febrile patients, elevated PCT may help predict bacteremia; furthermore, low PCT levels were helpful for ruling out bacteremia as a diagnosis. Therefore, PCT assessment could help physicians limit the number of prescriptions for antibiotics.
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