Evidence map›Paper›PMID 21319157›Full record

Trial reportCancer2011

Was race a factor in the outcomes of the Women's Health Eating and Living Study?

Raheem J Paxton, Lovell A Jones, Shine Chang, Mike Hernandez, Richard A Hajek, Shirley W Flatt, Loki Natarajan, John P Pierce

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00003787 (Dietary Intervention in Women Who Have Been Treated For Stage I, Stage II, or Stage III Breast Cancer), which is not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00003787 completednot on this map

Dietary Intervention in Women Who Have Been Treated For Stage I, Stage II, or Stage III Breast Cancer: Women's Healthy Eating and Living (WHEL) Study

TypeobservationalSponsorUniversity of California, San DiegoRan1995 to 2018Enrolled3,088ConditionsBreast CancerArmseducational/counseling intervention, therapeutic dietary intervention
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  2. Pooled it
  3. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
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  8. Article
  9. Article
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  11. Review
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  13. Health and Racial Disparity in Breast Cancer.Advances in experimental medicine and biology · 2019
    Review
  14. Article
  15. Review
  16. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raheem J PaxtonDepartment of Health Disparities Research, Center for Research on Minority Health, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. rjpaxton@mdanderson.org
Lovell A Jones
Shine Chang
Mike Hernandez
Richard A Hajek
Shirley W Flatt
Loki Natarajan
John P Pierce

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
RCT OF PLANT-BASED DIET IN BREAST CANCER RECURRENCER01CA069375 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIERCE, JOHN P · 1998 to 2007
$25.5M
R25 SUPPLEMENT IN GENETIC EPIDEMIOLOGY EDUCATIONR25CA057730 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHANG, SHINE · 1992 to 2016
$18.6M
Lifestyle Interventions for High-Risk Cancer SurvivorsK01CA158000 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAXTON, RAHEEM JAMAAL · 2011 to 2015
$639k
NCI NIH HHS CA016672NCI NIH HHS CA57730NCI NIH HHS CA69375NCI NIH HHS K01 CA158000NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA069375NCI NIH HHS R25 CA057730
6 · The paper itself

Abstract

backgroundThe objective of this study was to determine whether women who were participating in the Women's Healthy Eating and Living (WHEL) Study exhibited similar dietary changes, second breast cancer events, and overall survival regardless of race/ethnicity.

methodsFor this secondary analysis, the authors used data from 3013 women who were self-identified as Asian American, African American, Hispanic, or white and who were assigned randomly to a dietary intervention or a comparison group. Changes in dietary intake over time by race/ethnicity and intervention status were examined using linear mixed-effects models. Cox proportional hazards models were used to examine the effects of the intervention on the occurrence of second breast cancer events and overall survival. Statistical tests were 2-sided.

resultsAfrican Americans and Hispanics consumed significantly more calories from fat (+3.2%) and less fruit (-0.7 servings daily) than Asians and whites at baseline (all P < .01). Overall, intervention participants significantly improved their dietary pattern from baseline to the end of Year 1, reducing calories from fat by 4.9% and increasing intake of fiber (+6.6 grams daily), fruit (+1.1 servings daily), and vegetables (+1.6 servings daily; all P < .05). Despite improvements in the overall dietary pattern of these survivors, the intervention did not significantly influence second breast cancer events or overall survival.

conclusionsOverall, all racial groups significantly improved their dietary pattern over time, but the maintenance of these behaviors were lower among African-American women. More research and larger minority samples are needed to determine the specific factors that improve breast cancer-specific outcomes in diverse populations of survivors.

Indexed as

DietHealth BehaviorAsian PeopleBlack or African AmericanBreast NeoplasmsDietary FatsFeeding BehaviorFemaleHispanic or LatinoHumansMiddle AgedNeoplasm Recurrence, LocalPrognosisSurvivorsWhite PeopleWomen's HealthDietary Fats

Identifiers

PMID21319157
PMCPMC3135701

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.