Evidence map›Paper›PMID 21318902›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2011

Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.

Jatinder S Josan, Channa R De Silva, Byunghee Yoo, Ronald M Lynch, Mark D Pagel, Josef Vagner, Victor J Hruby

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Melanocortin 1 Receptor-Targeted α-Particle Therapy for Metastatic Uveal Melanoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
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  7. Hetero-bivalent GLP-1/glibenclamide for targeting pancreatic β-cells.Chembiochem : a European journal of chemical biology · 2014
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jatinder S JosanDepartment of Chemistry, University of Arizona, Tucson, AZ, USA.
Channa R De Silva
Byunghee Yoo
Ronald M Lynch
Mark D Pagel
Josef Vagner
Victor J Hruby
University of Arizona · US

Funding

Multimeric Ligands for Targeting of MelanomaR01CA097360 · NCI · UNIVERSITY OF ARIZONA · PI HRUBY, VICTOR J, MORSE, DAVID L · 2003 to 2012
$5.5M
Targeting Pancreatic CancerR01CA123547 · NCI · UNIVERSITY OF ARIZONA · PI MORSE, DAVID L · 2007 to 2011
$3.0M
Northeastern Ohio Animal Imaging Resource Center- NOAIRCR24CA110943 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI DUERK, JEFFREY L. · 2004 to 2006
$2.5M
Detection of in vivo protease activities using PARACEST MRI contrast agentsR21CA133455 · NCI · UNIVERSITY OF ARIZONA · PI PAGEL, MARK DAVID · 2008 to 2009
$374k
NCI NIH HHS R01 CA09736NCI NIH HHS R01 CA097360NCI NIH HHS R01 CA 123547NCI NIH HHS R01 CA123547NCI NIH HHS R21 CA133455NCI NIH HHS R21CA133455-01NCI NIH HHS R24 CA110943NCI NIH HHS R24CA110943
6 · The paper itself

Abstract

The use of fluorescent (or luminescent) and metal contrast agents in high-throughput screens, in vitro assays, and molecular imaging procedures has rapidly expanded in recent years. Here we describe the development and utility of high-affinity ligands for cancer theranostics and other in vitro screening -studies. In this context, we also illustrate the syntheses and use of heteromultivalent ligands as targeted imaging agents.

Indexed as

AnimalsBinding SitesCell LineChelating AgentsFluorescent DyesHeterocyclic Compounds, 1-RingHumansLanthanoid Series ElementsLigandsMagnetic Resonance ImagingMiceMicroscopy, FluorescenceMolecular ImagingNeoplasmsPentetic Acid1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidChelating AgentsFluorescent DyesHeterocyclic Compounds, 1-RingLanthanoid Series ElementsLigandsPentetic Acid

Identifiers

PMID21318902
PMCPMC3365840
OpenAlexW2335830708

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.