ArticleInternational orthopaedics2011
Duration of post-surgical antibiotic therapy for adult chronic osteomyelitis: a single-centre experience.
Article in International orthopaedics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05499481 (Short Against Long Antibiotic Therapy for Infected Orthopedic Sites), which is not on this map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Short Against Long Antibiotic Therapy for Infected Orthopedic Sites
Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- A recurrent OKC infected with actinomyces.BMC oral health · 2025Article
- Evaluating the antimicrobial and anti-inflammatory mechanisms of dexmedetomidine in managing bone infection: a laboratory perspective.BMC musculoskeletal disorders · 2025Article
- Inadequate empirical antibiotics following debridement for orthopedic infections do not increase therapy failures.Journal of bone and joint infection · 2025Article
- Exploring versatile applications of a vacuum-assisted bone harvester in orthopedic surgery.BMC musculoskeletal disorders · 2024Article
- Systemic Antimicrobial Treatment of Chronic Osteomyelitis in Adults: A Narrative Review.Antibiotics (Basel, Switzerland) · 2023Review
- Article
- Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Honey dressing: a missed way for orthopaedic wound care.International orthopaedics · 2022Article
- Femoral osteomyelitis caused by oral anaerobic bacteria with mixed bacteremia of Campylobacter rectus and Parvimonas micra in a chronic periodontitis patient: a case report.BMC infectious diseases · 2022Article
- One-stage debridement and bone transport versus first-stage debridement and second-stage bone transport for the management of lower limb post-traumatic osteomyelitis.Journal of orthopaedic translation · 2021Article
- Osteoarticular infections: a specific program for older patients?Aging clinical and experimental research · 2021Review
- Antibiotic treatment regimens for bone infection after debridement: a study of 902 cases.BMC musculoskeletal disorders · 2020Article
- Article
- Optimization of the antibiotic management of diabetic foot infections: protocol for two randomized controlled trials.Trials · 2020Article
- Oral Flucloxacillin for Treating Osteomyelitis: A Narrative Review of Clinical Practice.Journal of bone and joint infection · 2020Review
- Factors predictive of relapse in adult bacterial osteomyelitis of long bones.BMC infectious diseases · 2018Article
- Bacterial osteomyelitis: microbiological, clinical, therapeutic, and evolutive characteristics of 344 episodes.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018Article
- Pressure ulcer-related pelvic osteomyelitis: evaluation of a two-stage surgical strategy (debridement, negative pressure therapy and flap coverage) with prolonged antimicrobial therapy.BMC infectious diseases · 2018Article
- Chronic Osteomyelitis - Bacterial Flora, Antibiotic Sensitivity and Treatment Challenges.The open orthopaedics journal · 2018Article
- Variables associated with remission in spinal surgical site infections.Journal of spine surgery (Hong Kong) · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe optimal duration of concomitant antibiotic therapy after surgical intervention for implant-free chronic osteomyelitis is unknown. No randomized data exist. Available recommendations are based on expert's opinion. We evaluated the duration of post-surgical antibiotic treatment related to remission of chronic osteomyelitis.
methodsThis was a retrospective single-centre study at Geneva University Hospitals with a minimal follow-up of two years after treatment. We used multivariate logistic regression analysis with exclusion of pediatric cases and of implant-related chronic osteomyelitis.
resultsA total of 49 episodes of implant-free chronic osteomyelitis in 49 adult patients were studied. The median number of surgical interventions was two (range, 1-10). The median duration of post-debridement antibiotic treatment was eight weeks (range, 4-14 weeks). Thirty-nine patients (80%) were in remission after a minimal follow-up of two years. In multivariate logistic regression analysis, one week of intravenous therapy had the same remission as two to three weeks (0.2, 0.1-1.9) or ≥ 3 weeks (0.3, 0.1-2.4). More than six weeks of total antibiotic treatment equalled ≤ six weeks (0.8, 0.1-5.2).
conclusionsIn chronic osteomyelitis in adults, a post-debridement antibiotic therapy beyond six weeks, or an IV treatment longer than one week, did not show enhanced remission incidences. Prospective randomized trials are required to confirm this observation.
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