ArticleJournal of neuro-oncology2011
Competing for patients: an ethical framework for recruiting patients with brain tumors into clinical trials.
Article in Journal of neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effects of Brain Tumours upon Medical Decision-Making Capacity.Current oncology reports · 2019Pooled it
- A tripartite model for recruiting African-Americans into fatherhood intervention research.Public health nursing (Boston, Mass.) · 2018Trial
- Recruitment across two decades of NIH-funded Alzheimer's disease clinical trials.Alzheimer's research & therapy · 2023Article
- Review
- Allocation of Opportunities to Participate in Clinical Trials during the Covid-19 Pandemic and Other Public Health Emergencies.The Hastings Center report · 2022Article
- Improving the Efficiency of Clinical Trial Recruitment Using an Ensemble Machine Learning to Assist With Eligibility Screening.ACR open rheumatology · 2021Article
- A Time-and-Motion Study of Clinical Trial Eligibility Screening in a Pediatric Emergency Department.Pediatric emergency care · 2019Observational
- Ethical issues in competing clinical trials.Contemporary clinical trials communications · 2019Article
- When clinical trials compete: prioritising study recruitment.Journal of medical ethics · 2017Article
- Automated clinical trial eligibility prescreening: increasing the efficiency of patient identification for clinical trials in the emergency department.Journal of the American Medical Informatics Association : JAMIA · 2015Article
- Ethical and scientific considerations for patient enrollment into concurrent clinical trials.Trials · 2014Review
- Pediatric clinical trials.Perspectives in clinical research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With more rapid advances in potential treatments for brain tumours, the number of clinical trials for brain tumour patients is rising. In the context of the challenges of recruitment and enrollment of patients with brain tumors, the dichotomy between the paucity of subjects and abundance of clinical trials creates a unique ethical dilemma, whereby a single patient may be eligible for several studies. Here, we identify and present three approaches for recruiting and enrolling patients who may be eligible for several trials. The ethical implications of the full disclosure, paternalistic, and random approaches are discussed. The full disclosure approach presents information to patients regarding all ongoing concurrent trials, allowing them to make an informed decision, while the paternalistic approach allows the healthcare providers to select the trial for which they believe the patient is most suitable. These introduce the biases into circumstances where equipoise is necessary and risk selection bias in study design. The random approach randomly allocates patients to each trial, which may erode patient autonomy and decrease trial enrollment. Brain tumor patients comprise a vulnerable population and it remains incumbent on healthcare providers to maintain the highest ethical standards when approaching them for clinical research. Changes in clinical trial design are required to mitigate the conflicts created by competition for patients.
Indexed as
Identifiers
21318320What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.