ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2011
Aged garlic extract scavenges superoxide radicals.
Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- The effectiveness of garlic (Research in pharmaceutical sciences · 2025Article
- Effects of aged garlic extract on experimental periodontitis in mice.Biomedical reports · 2025Article
- Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies.Natural products and bioprospecting · 2023Review
- The nutritional value, bioactive availability and functional properties of garlic and its related products during processing.Frontiers in nutrition · 2023Review
- Assessment of standardization of domestic commercial black garlic extract forFood science and biotechnology · 2022Article
- Cytoprotective Potential of Aged Garlic Extract (AGE) and Its Active Constituent, S-allyl-l-cysteine, in Presence of Carvedilol during Isoproterenol-Induced Myocardial Disturbance and Metabolic Derangements in Rats.Molecules (Basel, Switzerland) · 2021Article
- Plants Used as Antihypertensive.Natural products and bioprospecting · 2021Review
- BACH1 mediates the antioxidant properties of aged garlic extract.Experimental and therapeutic medicine · 2020Review
- Bioactive components from garlic on brain resiliency against neuroinflammation and neurodegeneration.Experimental and therapeutic medicine · 2020Review
- Review
- TheRSC advances · 2019Article
- Development of a Method and Validation for the Quantitation of FruArg in Mice Plasma and Brain Tissue Using UPLC-MS/MS.ACS omega · 2016Article
- Effects of aged garlic extract and FruArg on gene expression and signaling pathways in lipopolysaccharide-activated microglial cells.Scientific reports · 2016Article
- Effect of Allium flavum L. and Allium melanantherum Panč. Extracts on Oxidative DNA Damage and Antioxidative Enzymes Superoxide Dismutase and Catalase.Plant foods for human nutrition (Dordrecht, Netherlands) · 2016Article
- Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats.BMC complementary and alternative medicine · 2016Article
- Anti-hypertensive Herbs and their Mechanisms of Action: Part I.Frontiers in pharmacology · 2015Review
- Antioxidant and hypolipidemic potential of aged garlic extract and its constituent, s-allyl cysteine, in rats.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- The protective effect of aged garlic extract on nonsteroidal anti-inflammatory drug-induced gastric inflammations in male albino rats.Evidence-based complementary and alternative medicine : eCAM · 2014Article
- The durative use of suspension cells and callus for volatile oil by comparative with seeds and fruits in Capparis spinosa L.PloS one · 2014Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is increasing evidence to suggest that many degenerative or pathological processes, such as aging, cancer, and coronary heart disease, are related to reactive oxygen species and radical-mediated reactions. We examined the effectiveness of aged garlic extract (AGE), a garlic preparation rich in water-soluble cysteinyl moieties, and its component for scavenging of superoxide by using the hypoxanthine-xanthine oxidase and human neutrophils. In the hypoxanthine-xanthine oxidase system, electron spin resonance showed that aged garlic extract scavenged superoxide radicals in a dose-dependent manner up to 54%. The EC(50) value of aged garlic extract for the superoxide radical scavenging effect was 0.80 mg/ml. N-α-(1-deoxy-D-fructos-1-yl)-L-arginine (25.9%) and (1S, 3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-1,3-dicarboxylic acid (20.8%), water-soluble moieties of AGE, also exerted superoxide scavenging effects. Phorbol 12-myristate 13-acetate-activated human neutrophils produced superoxide radical of 56.6 ± 9.27 nmol/min/10(7) cells. Aged garlic extract (3 mg/ml) significantly inhibited superoxide production in comparison to the control. These data suggest that aged garlic extract may be useful for preventing diseases associated with reactive oxygen species.
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