ReviewPflugers Archiv : European journal of physiology2011
Role of cellular mechanics in the function and life span of vascular endothelium.
Review in Pflugers Archiv : European journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 72 citations in OpenAlex.
- Vascular endothelial cellular mechanics under hyperglycemia and its role in tissue regeneration.Regenerative biomaterials · 2024Article
- Review
- The Soluble Fms-like Tyrosine Kinase-1 Contributes to Structural and Functional Changes in Endothelial Cells in Chronic Kidney Disease.International journal of molecular sciences · 2022Article
- Overcoming High Impedance in the Transitional Area of the Distal Great Cardiac Vein during Radiofrequency Catheter Ablation of Ventricular Arrhythmia.Journal of cardiovascular development and disease · 2022Article
- On non-Kolmogorov turbulence in blood flow and its possible role in mechanobiological stimulation.Scientific reports · 2022Article
- Pathophysiology of Spontaneous Coronary Artery Dissection Determines Anticoagulation Strategy.Cureus · 2021Review
- High NaBiomedicines · 2021Review
- Sustained Maternal Smoking Triggers Endothelial-Mediated Oxidative Stress in the Umbilical Cord Vessels, Resulting in Vascular Dysfunction.Antioxidants (Basel, Switzerland) · 2021Article
- The Functional Implications of Endothelial Gap Junctions and Cellular Mechanics in Vascular Angiogenesis.Cancers · 2019Review
- Chronic hypertension increases aortic endothelial hydraulic conductivity by upregulating endothelial aquaporin-1 expression.American journal of physiology. Heart and circulatory physiology · 2017Article
- Salt-induced NaPflugers Archiv : European journal of physiology · 2017Article
- Regulation of the hematopoietic stem cell lifecycle by the endothelial niche.Current opinion in hematology · 2017Review
- Interaction of endothelial cells with macrophages-linking molecular and metabolic signaling.Pflugers Archiv : European journal of physiology · 2017Review
- Markers and Biomarkers of Endothelium: When Something Is Rotten in the State.Oxidative medicine and cellular longevity · 2017Review
- Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function.Antioxidants & redox signaling · 2016Review
- Impact of Simulated Microgravity on Cytoskeleton and Viscoelastic Properties of Endothelial Cell.Scientific reports · 2016Article
- Lack of vimentin impairs endothelial differentiation of embryonic stem cells.Scientific reports · 2016Article
- Feeling for Filaments: Quantification of the Cortical Actin Web in Live Vascular Endothelium.Biophysical journal · 2015Article
- Age-associated pro-inflammatory remodeling and functional phenotype in the heart and large arteries.Journal of molecular and cellular cardiology · 2015Review
- Application of multiple levels of fluid shear stress to endothelial cells plated on polyacrylamide gels.Lab on a chip · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vascular endothelium plays a crucial role in vessel homeostasis and is implicated in the pathogenesis of cardiovascular disease. The function and life span of endothelial cells, therefore, have a large impact upon the quality and expectancy of an individual's life. Exposure to haemodynamic forces determines the phenotype of endothelial cells. Turbulent blood flow, disturbed shear stress and a rising tension of the vessel wall result in endothelial dysfunction and an enhanced endothelial cell turnover. In this scenario, the role of endothelial mechanics is yet poorly described. The streaming blood exerts shear forces transmitted to the soft cortical actin mesh immediately underneath the plasma membrane. The mechanical properties of this actin cortex seem to be an important regulator of endothelial function. Aldosterone and high plasma sodium stiffen the endothelial cell cortex which is accompanied by a decrease in NO release. If endothelial stiffening is only transient, it may be a useful mechanism to compensate for any decrease in arterial blood pressure. Long-term stiffening of the cell, however, may lead to endothelial dysfunction and may contribute to cardiovascular disorders, as observed in disturbed aldosterone/sodium homeostasis. In this case, the mineralocorticoid receptor antagonist spironolactone maintains the endothelial cell cortex soft and thereby preserves normal endothelial function and longevity. This may explain the recently observed beneficial effects of spironolactone on the cardiovascular system. Taken together, the review highlights the importance of elasticity for normal endothelial function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.