ArticleEURASIP journal on bioinformatics & systems biology2010
TRII: A Probabilistic Scoring of Drosophila melanogaster Translation Initiation Sites.
Article in EURASIP journal on bioinformatics & systems biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Amino termini of many yeast proteins map to downstream start codons.Journal of proteome research · 2012Article
- Using translational enhancers to increase transgene expression in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
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2 authors.
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Abstract
Relative individual information is a measurement that scores the quality of DNA- and RNA-binding sites for biological machines. The development of analytical approaches to increase the power of this scoring method will improve its utility in evaluating the functions of motifs. In this study, the scoring method was applied to potential translation initiation sites in Drosophila to compute Translation Relative Individual Information (TRII) scores. The weight matrix at the core of the scoring method was optimized based on high-confidence translation initiation sites identified by using a progressive partitioning approach. Comparing the distributions of TRII scores for sites of interest with those for high-confidence translation initiation sites and random sequences provides a new methodology for assessing the quality of translation initiation sites. The optimized weight matrices can also be used to describe the consensus at translation initiation sites, providing a quantitative measure of preferred and avoided nucleotides at each position.
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