Evidence map›Paper›PMID 21318072›Full record

ReviewWiley interdisciplinary reviews. RNA

The small subunit processome in ribosome biogenesis—progress and prospects.

Kathleen R Phipps, J Michael Charette, Susan J Baserga

Open access · greenAbstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 167 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. VIRMA-mediated mScience advances · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Global Transcriptome Profile of the Oleaginous YeastJournal of fungi (Basel, Switzerland) · 2021
    Article
  18. Article
  19. Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kathleen R PhippsDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT, USA.
J Michael Charette
Susan J Baserga
Yale University · US

Funding

Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
The Architecture and Function of RNPs Required for Ribosome BiogenesisR01GM052581 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 2001 to 2013
$4.4M
RESEARCH TRAINING: RADIATION THERAPY, BIOLOGY, PHYSICST32CA009259 · NCI · YALE UNIVERSITY · PI GLAZER, PETER M · 1985 to 2009
$1.4M
ASSEMBLY, LOCALIZATION AND FUNCTION OF THE U3 SNRNPR29GM052581 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1996 to 2000
$120k
NCI NIH HHS T32 CA009259NIGMS NIH HHS GM 52581NIGMS NIH HHS R01 GM052581NIGMS NIH HHS R29 GM052581NIGMS NIH HHS T32 GM007223
6 · The paper itself

Abstract

The small subunit (SSU) processome is a 2.2-MDa ribonucleoprotein complex involved in the processing, assembly, and maturation of the SSU of eukaryotic ribosomes. The identities of many of the factors involved in SSU biogenesis have been elucidated over the past 40 years. However, as our understanding increases, so do the number of questions about the nature of this complicated process. Cataloging the components is the first step toward understanding the molecular workings of a system. This review will focus on how identifying components of ribosome biogenesis has led to the knowledge of how these factors, protein and RNA alike, associate with one another into subcomplexes, with a concentration on the small ribosomal subunit. We will also explore how this knowledge of subcomplex assembly has informed our understanding of the workings of the ribosome synthesis system as a whole.

Indexed as

Protein Modification, TranslationalAnimalsEukaryotaHumansModels, BiologicalModels, MolecularNucleic Acid ConformationRibonucleoproteinsRibosomesRibosome Subunits, SmallRNA, Ribosomal, 18SRNA, Small NucleolarRibonucleoproteinsRNA, Ribosomal, 18SRNA, Small Nucleolarribosomal SSURNA chaperoneRNA processingSSU processomeU3 snoRNAUtp

Identifiers

PMID21318072
PMCPMC3035417
OpenAlexW2083610145

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.