ReviewInternational journal of environmental research and public health2011
Smoking related diseases: the central role of monoamine oxidase.
Review in International journal of environmental research and public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- The highs and lows of monoamine oxidase as molecular target in cancer: an updated review.Molecular and cellular biochemistry · 2025Review
- Design, synthesis, molecular modelling andRoyal Society open science · 2020Article
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- Article
- Observational
- Smoking habits and coenzyme Q10 status in healthy European adults.Archives of medical science : AMS · 2016Article
- Does quitting smoking decrease the risk of midlife hot flashes? A longitudinal analysis.Maturitas · 2015Article
- Influence of Altered Hormonal Status on Platelet 5-HT and MAO-B Activity in Cigarette Smokers.Indian journal of clinical biochemistry : IJCB · 2015Article
- Article
- Bacoside A: Role in Cigarette Smoking Induced Changes in Brain.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways.Brain and behavior · 2013Article
- Genetics of schizophrenia and smoking: an approach to studying their comorbidity based on epidemiological findings.Human genetics · 2012Review
- Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells.Bioconjugate chemistry · 2012Article
- Reduced coenzyme Q(10) in female smokers and its association with lipid profile in a young healthy adult population.Archives of medical science : AMS · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Smoking is a major risk factor of morbidity and mortality. It is well established that monoamine oxidase (MAO) activity is decreased in smokers. Serotonin (5-HT), a major substrate for MAO that circulates as a reserve pool stored in platelets, is a marker of platelet activation. We recently reported that smoking durably modifies the platelet 5-HT/MAO system by inducing a demethylation of the MAO gene promoter resulting in high MAO protein concentration persisting more than ten years after quitting smoking. The present data enlarges the results to another MAO substrate, norepinephrine (NE), further confirming the central role of MAO in tobacco use-induced diseases. Thus, MAO could be a readily accessible and helpful marker in the risk evaluation of smoking-related diseases, from cardiovascular and pulmonary diseases to depression, anxiety and cancer. The present review implements the new finding of epigenetic regulation of MAO and suggests that smoking-induced MAO demethylation can be considered as a hallmark of smoking-related cancers similarly to other aberrant DNA methylations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.