Evidence map›Paper›PMID 21317447›Full record

ReviewOncotarget2010

Standards and impact of hematopathology in myelodysplastic syndromes (MDS).

Peter Valent, Attilio Orazi, Guntram Büsche, Annette Schmitt-Gräff, Tracy I George, Karl Sotlar, Berthold Streubel, Christine Beham-Schmid, Sabine Cerny-Reiterer, Otto Krieger and 10 more

Open access · hybridAbstract readReview
In one paragraph

Review in Oncotarget, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Association between glutathione S-transferase T1 null genotype and risk of myelodysplastic syndromes: a comprehensive meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Pooled it
  2. Article
  3. Infrared Spectroscopy: A New Frontier in Hematological Disease Diagnosis.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications.Pathobiology : journal of immunopathology, molecular and cellular biology · 2019
    Review
  7. The underestimated role of basophils in PhEuropean journal of clinical investigation · 2018
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Importance of classical morphology in the diagnosis of myelodysplastic syndrome.Mediterranean journal of hematology and infectious diseases · 2015
    Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 12 institutions in 6 countries.

Peter ValentDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria.
Attilio OraziNew York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA.
Guntram BüscheInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Annette Schmitt-GräffDepartment of Pathology, University of Freiburg, Germany.
Tracy I GeorgeDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Karl SotlarInstitute of Pathology, University of Munich.
Berthold StreubelInstitute of Pathology, Medical University of Vienna.
Christine Beham-SchmidInstitute of Pathology, Medical University of Graz, Austria.
Sabine Cerny-ReitererDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria.
Otto KriegerFirst Department of Internal Medicine, Elisabethinen Hospital Linz, Austria.
Arjan van de LoosdrechtVU University Medical Center, Amsterdam, The Netherlands.
Wolfgang KernMLL Munich Leukemia Laboratory, Munich, Germany.
Kiyoyuki OgataDivision of Hematology, Department of Medicine, Nippon Medical School, Tokyo, Japan.
Friedrich WimazalDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria.
Judit CsomorInstitute of Pathology, Semmelweis University, Budapest, Hungary.
Judit VárkonyiDepartment of Hematology, Semmelweis University, Budapest, Hungary.
Wolfgang R SperrDepartment of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria.
Martin WernerDepartment of Pathology, University of Freiburg, Germany.
Hans KreipeInstitute of Pathology, Hannover Medical School, Hannover, Germany.
Horny Hans-PeterInstitute of Pathology, Ansbach, Germany.
Medical University of Vienna · ATMedizinische Hochschule Hannover · DESemmelweis University · HUUniversity of Freiburg · DEAmsterdam UMC Location VUmc · NLKrankenhaus der Elisabethinen · ATLudwig-Maximilians-Universität München · DEMedical University of Graz · ATMunich Leukemia Laboratory (Germany) · DENewYork–Presbyterian Hospital · USNippon Medical School · JPStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The diagnosis, classification, and prognostication of patients with myelodysplastic syndromes (MDS) are usually based on clinical parameters, analysis of peripheral blood and bone marrow smears, and cytogenetic determinants. However, a thorough histologic and immunohistochemical examination of the bone marrow is often required for a final diagnosis and exact classification in these patients. Notably, histology and immunohistology may reveal dysplasia in megakaryocytes or other bone marrow lineages and/or the presence of clusters of CD34-positive precursor cells. In other cases, histology may reveal an unrelated or co-existing hematopoietic neoplasm, or may support the conclusion the patient is suffering from acute myeloid leukemia rather than MDS. Moreover, histologic investigations and immunohistology may reveal an increase in tryptase-positive cells, a coexisting systemic mastocytosis, or bone marrow fibrosis, which is of prognostic significance. To discuss diagnostic algorithms, terminologies, parameters, and specific issues in the hematopathologic evaluation of MDS, a Working Conference involving a consortium of US and EU experts, was organized in June 2010. The outcomes of the conference and resulting recommendations provided by the faculty, are reported in this article. These guidelines should assist in the diagnosis, classification, and prognostication in MDS in daily practice as well as in clinical trials.

Indexed as

Biomarkers, TumorBone Marrow CellsClinical Laboratory TechniquesGuidelines as TopicHematologic TestsHumansImmunohistochemistryMyelodysplastic SyndromesPrognosisReference StandardsBiomarkers, Tumor

Identifiers

PMID21317447
PMCPMC3248141
OpenAlexW2142040997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.