ArticleThe Journal of biological chemistry2011
DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Atypical Hippo signaling network: uncovering novel insights into head and neck cancer biology and advancements in precision intervention.Frontiers in cell and developmental biology · 2025Review
- Hypoxia-activated XBP1s recruits HDAC2-EZH2 to engage epigenetic suppression of ΔNp63α expression and promote breast cancer metastasis independent of HIF1α.Cell death and differentiation · 2024Article
- Differentiated Embryo-Chondrocyte Expressed Gene1 and Parkinson's Disease: New Insights and Therapeutic Perspectives.Current neuropharmacology · 2023Review
- Bhlhe40 differentially regulates the function and number of peroxisomes and mitochondria in myogenic cells.Redox biology · 2019Article
- BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion.Breast cancer research : BCR · 2018Article
- Microbiome precision editing: Using PEG as a selective fermentation initiator against methicillin-resistant Staphylococcus aureus.Biotechnology journal · 2017Article
- Article
- Two-stage induced differentiation of OCT4+/Nanog+ stem-like cells in lung adenocarcinoma.Oncotarget · 2016Article
- ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation.Nucleic acids research · 2015Article
- Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects.Respiratory research · 2015Article
- Bhlhe40 Represses PGC-1α Activity on Metabolic Gene Promoters in Myogenic Cells.Molecular and cellular biology · 2015Article
- p53/p63/p73 in the epidermis in health and disease.Cold Spring Harbor perspectives in medicine · 2014Review
- RNA-binding protein RBM24 regulates p63 expression via mRNA stability.Molecular cancer research : MCR · 2014Article
- Article
- A nanotechnological, molecular-modeling, and immunological approach to study the interaction of the anti-tumorigenic peptide p28 with the p53 family of proteins.International journal of nanomedicine · 2014Article
- Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63.The Journal of investigative dermatology · 2013Article
- TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function.The Journal of biological chemistry · 2013Article
- DEC1 and MIC-1: new players of p53-dependent cell fate decision.Cell cycle (Georgetown, Tex.) · 2012Article
- p53, a target of estrogen receptor (ER) α, modulates DNA damage-induced growth suppression in ER-positive breast cancer cells.The Journal of biological chemistry · 2012Article
- Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The p63 gene, a member of the p53 family, is expressed as TA and ΔN isoforms. ΔNp63 is the predominant isoform expressed in cells of epithelial origin and frequently overexpressed in cancers. However, what regulates p63 expression is uncertain. Here, we showed that ΔNp63 is regulated by the transcription factor DEC1, a p53 family target. We also showed that the ability of DEC1 to regulate ΔNp63 is enhanced by histone deacetylase (HDAC) inhibitors or knockdown of histone deacetylase 2 (HDAC2). Consistent with this, we found that DEC1 and HDAC2 physically interact and knockdown of HDAC2 leads to increased binding of DEC1 to the ΔNp63 promoter. Interestingly, we found that growth suppression induced by HDAC inhibitors is attenuated by ectopic expression of DEC1 in a ΔNp63-dependent manner. In addition, we showed that ectopic expression of DEC1 inhibits, whereas knockdown of DEC1 promotes, keratinocyte differentiation via modulating ΔNp63 expression. Finally, we showed that DEC1 cooperates with HDAC inhibitors to further decrease keratinocyte differentiation. Together, we conclude that ΔNp63 is a novel target of DEC1 and HDAC2 and modulates the efficacy of HDAC inhibitors in growth suppression and keratinocyte differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.