ArticleGut2011
Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease.
Article in Gut, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Guideline
- ACG clinical guidelines: diagnosis and management of celiac disease.The American journal of gastroenterology · 2013Guideline
- Trial
- Potential Transfer of Toxic Gluten from Biodegradable Tableware to Gluten-Free Foods: Implications for Individuals with Gluten-Related Disorders.Journal of agricultural and food chemistry · 2025Article
- Effects of Perfluorooctane Sulfonic Acid Exposure on Intestinal Microbial Community, Lipid Metabolism, and Liver Lesions in Mice.International journal of molecular sciences · 2025Article
- Does sourdough bread provide clinically relevant health benefits?Frontiers in nutrition · 2023Review
- A Highly Sensitive Method for the Detection of Hydrolyzed Gluten in Beer Samples Using LFIA.Foods (Basel, Switzerland) · 2022Article
- Challenges in Gluten Analysis: A Comparison of Four Commercial Sandwich ELISA Kits.Foods (Basel, Switzerland) · 2022Article
- Quantification of Barley Contaminants in Gluten-Free Oats by Four Gluten ELISA Kits.Journal of agricultural and food chemistry · 2022Article
- Specific Avenin Cross-Reactivity with G12 Antibody in a Wide Range of Current Oat Cultivars.Foods (Basel, Switzerland) · 2022Article
- Effect of additional water supply during grain filling on protein composition and epitope characteristics of winter oats.Current research in food science · 2022Article
- Immunonutritional Protease Inhibitors fromInternational journal of molecular sciences · 2021Article
- Review
- Ancient and Modern Cereals as Ingredients of the Gluten-Free Diet: Are They Safe Enough for Celiac Consumers?Foods (Basel, Switzerland) · 2021Review
- Rapid, Effective, and Versatile Extraction of Gluten in Food with Application on Different Immunological Methods.Foods (Basel, Switzerland) · 2021Article
- Investigation of Protein and Epitope Characteristics of Oats and Its Implications for Celiac Disease.Frontiers in nutrition · 2021Article
- Oats as a Safe Alternative to Triticeae Cereals for People Suffering from Celiac Disease? A Review.Plant foods for human nutrition (Dordrecht, Netherlands) · 2020Review
- Mediterranean Gluten-Free Diet: Is It a Fair Bet for the Treatment of Gluten-Related Disorders?Frontiers in nutrition · 2020Review
- To Be Oats or Not to Be? An Update on the Ongoing Debate on Oats for Patients With Celiac Disease.Frontiers in pediatrics · 2019Review
- Preparation and Characterization of Avenin-Enriched Oat Protein by Chill Precipitation for Feeding Trials in Celiac Disease.Frontiers in nutrition · 2019Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsCoeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patients with CD. Monoclonal antibodies (moAbs) against the main immunotoxic 33-mer peptide (A1 and G12) react strongly against wheat, barley and rye but have less reactivity against oats. The stated aim of this study is to test whether this observed reactivity could be related to the potential toxicity of oats for patients with CD.
methodsIn the present study, different oat varieties, controlled for their purity and by their distinct protein pattern, were used to examine differences in moAb G12 recognition by ELISA and western blot. Immunogenicity of oat varieties was determined by 33-mer concentration, T cell proliferation and interferon γ production.
resultsThree groups of oat cultivars reacting differently against moAb G12 could be distinguished: a group with considerable affinity, a group showing slight reactivity and a third with no detectable reactivity. The immunogenicity of the three types of oats as well as that of a positive and negative control was determined with isolated peripheral blood mononuclear T cells from patients with CD by measurement of cell proliferation and interferon γ release. A direct correlation of the reactivity with G12 and the immunogenicity of the different prolamins was observed.
conclusionsThe results showed that the reactivity of the moAb G12 is proportional to the potential immunotoxicity of the cereal cultivar. These differences may explain the different clinical responses observed in patients suffering from CD and open up a means to identify immunologically safe oat cultivars, which could be used to enrich a gluten-free diet.
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Registered trials
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