ArticleAmerican journal of respiratory cell and molecular biology2011
Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung.
Article in American journal of respiratory cell and molecular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- ErbB4 alternative splicing mediates fetal mouse alveolar type II cell differentiation in vitro.Pediatric research · 2022Article
- Proteolytic Cleavage of Receptor Tyrosine Kinases.Biomolecules · 2021Review
- Review
- TheJournal of cell science · 2018Article
- Expression of surfactant protein B is dependent on cell density in H441 lung epithelial cells.PloS one · 2017Article
- Cigarette Smoke Induces Human Epidermal Receptor 2-Dependent Changes in Epithelial Permeability.American journal of respiratory cell and molecular biology · 2016Article
- Article
- Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases.The FEBS journal · 2015Review
- Interdependent TTF1 - ErbB4 interactions are critical for surfactant protein-B homeostasis in primary mouse lung alveolar type II cells.Journal of cell communication and signaling · 2015Article
- Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities.The European respiratory journal · 2014Review
- ErbB4 is an upstream regulator of TTF-1 fetal mouse lung type II cell development in vitro.Biochimica et biophysica acta · 2013Article
- Receptor tyrosine kinases in the nucleus.Cold Spring Harbor perspectives in biology · 2013Review
- Adult Rat Bone Marrow-Derived Stem Cells Promote Late Fetal Type II Cell Differentiation in a Co-Culture Model.The open respiratory medicine journal · 2013Article
- Human epidermal growth factor receptor signaling in acute lung injury.American journal of respiratory cell and molecular biology · 2012Review
- Stretch-induced fetal type II cell differentiation is mediated via ErbB1-ErbB4 interactions.The Journal of biological chemistry · 2012Article
- Synergistic effect of caffeine and glucocorticoids on expression of surfactant protein B (SP-B) mRNA.PloS one · 2012Article
- Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells.Biochimica et biophysica acta · 2011Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Sufficient pulmonary surfactant production is required for the fetal-neonatal transition, especially in preterm infants. Neuregulin (NRG) and its transmembrane receptor ErbB4 positively regulate the onset of fetal surfactant synthesis. Details of this signaling process remain to be elucidated. ErbB4 is known to regulate gene expression in the mammary gland, where the receptor associates with the signal transducer and activator of transcription Stat5a to transactivate the β-casein gene promoter. We hypothesized that in the fetal lung, ErbB4 functions as a transcriptional regulator for surfactant protein B (Sftpb), the most critical surfactant protein gene. Re-expressing full-length ErbB4 in primary fetal ErbB4-depleted Type II epithelial cells led to an increased expression of Sftpb mRNA. This stimulatory effect required the nuclear translocation of ErbB4 and association with Stat5a, with the resultant binding to and activation of the Sftpb promoter. We conclude that ErbB4 directly regulates important aspects of fetal lung maturation that help prepare for the fetal-neonatal transition.
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