ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Differential vulnerability of skeletal muscle feed arteries to dysfunction in insulin resistance: impact of fiber type and daily activity.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition.Microcirculation (New York, N.Y. : 1994) · 2019Article
- Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain.Exercise and sport sciences reviews · 2019Review
- Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: A unique vascular transcriptomic signature.Pharmacological research · 2018Article
- Article
- Insulin resistance: vascular function and exercise.Integrative medicine research · 2016Review
- Endurance, interval sprint, and resistance exercise training: impact on microvascular dysfunction in type 2 diabetes.American journal of physiology. Heart and circulatory physiology · 2016Review
- Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Review
- Exercise-induced differential changes in gene expression among arterioles of skeletal muscles of obese rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Exercise training causes differential changes in gene expression in diaphragm arteries and 2A arterioles of obese rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Regional variation in arterial stiffening and dysfunction in Western diet-induced obesity.American journal of physiology. Heart and circulatory physiology · 2015Article
- Modulation of endothelial cell phenotype by physical activity: impact on obesity-related endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2015Review
- Identification of genes whose expression is altered by obesity throughout the arterial tree.Physiological genomics · 2014Article
- Reduced hepatic eNOS phosphorylation is associated with NAFLD and type 2 diabetes progression and is prevented by daily exercise in hyperphagic OLETF rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia.The Journal of physiology · 2014Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Differential vasomotor effects of insulin on gastrocnemius and soleus feed arteries in the OLETF rat model: role of endothelin-1.Experimental physiology · 2014Article
- Metformin does not enhance insulin-stimulated vasodilation in skeletal muscle resistance arteries of the OLETF rat.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease?Diabetes · 2013Review
- Voluntary wheel running selectively augments insulin-stimulated vasodilation in arterioles from white skeletal muscle of insulin-resistant rats.Microcirculation (New York, N.Y. : 1994) · 2012Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Functional and structural heterogeneity exists among skeletal muscle vascular beds related, in part, to muscle fiber type composition. This study was designed to delineate whether the vulnerability to vascular dysfunction in insulin resistance is uniformly distributed among skeletal muscle vasculatures and whether physical activity modifies this vulnerability. Obese, hyperphagic Otsuka Long-Evans Tokushima fatty rats (20 wk old) were sedentary (OSED) or physically active (OPA; access to running wheels) and compared with age-matched sedentary Long-Evans Tokushima Otsuka (LSED) rats. Vascular responses were determined in isolated, pressurized feed arteries from fast-twitch gastrocnemius (GFAs) and slow-twitch soleus (SFAs) muscles. OSED animals were obese, insulin resistant, and hypertriglyceridemic, traits absent in LSED and OPA rats. GFAs from OSED animals exhibited depressed dilation to ACh, but not sodium nitroprusside, and enhanced vasoconstriction to endothelin-1 (ET-1), but not phenylephrine, compared with those in LSED. Immunoblot analysis suggests reduced endothelial nitric oxide synthase phosphorylation at Ser1177 and endothelin subtype A receptor expression in OSED GFAs. Physical activity prevented reduced nitric oxide-dependent dilation to ACh, but not enhanced ET-1 vasoconstriction, in GFA from OPA animals. Conversely, vasoreactivity of SFAs to ACh and ET-1 were principally similar in all groups, whereas dilation to sodium nitroprusside was enhanced in OSED and OPA rats. These data demonstrate, for the first time, that SFAs from insulin-resistant rats exhibit reduced vulnerability to dysfunction versus GFAs and that physical activity largely prevents GFA dysfunction. We conclude that these results demonstrate that vascular dysfunction associated with insulin resistance is heterogeneously distributed across skeletal muscle vasculatures related, in part, to muscle fiber type and activity level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.