ArticleThe Journal of biological chemistry2011
The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Exploring the Functional Landscape of the p53 Regulatory Domain: The Stabilizing Role of Post-Translational Modifications.Journal of chemical theory and computation · 2024Article
- Unveiling the role of GAS41 in cancer progression.Cancer cell international · 2023Review
- Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.Molecular cell · 2023Article
- Maintaining Genome Integrity: Protein Kinases and Phosphatases Orchestrate the Balancing Act of DNA Double-Strand Breaks Repair in Cancer.International journal of molecular sciences · 2023Review
- Mechanistic insights into genomic structure and functions of a novel oncogene YEATS4.Frontiers in cell and developmental biology · 2023Review
- Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases.Cellular and molecular life sciences : CMLS · 2022Review
- The Role of the Ubiquitin Proteasome System in Glioma: Analysis Emphasizing the Main Molecular Players and Therapeutic Strategies Identified in Glioblastoma Multiforme.Molecular neurobiology · 2021Review
- YEATS4 is associated with poor prognosis and promotes epithelial-to-mesenchymal transition and metastasis by regulating ZEB1 expression in breast cancer.American journal of cancer research · 2021Article
- p53 modifications: exquisite decorations of the powerful guardian.Journal of molecular cell biology · 2019Review
- Understanding p53 functions through p53 antibodies.Journal of molecular cell biology · 2019Review
- Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.American journal of cancer research · 2018Article
- Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer.Genes & development · 2018Article
- Identification of commonly altered genes between in major depressive disorder and a mouse model of depression.Scientific reports · 2017Article
- The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.Oncogene · 2016Article
- miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Knockdown of YEATS4 inhibits colorectal cancer cell proliferation and induces apoptosis.American journal of translational research · 2015Article
- GAS41 amplification results in overexpression of a new spindle pole protein.Genes, chromosomes & cancer · 2012Article
- The ubiquitin-proteasome system in glioma cell cycle control.Cell division · 2012Article
- Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The p53 tumor suppressor is principally regulated by post-translational modifications and proteasome-dependent degradation. Various kinases have been shown to phosphorylate p53, but little is known about the counteracting phosphatases. We demonstrate here that the newly identified complex GAS41-PP2Cβ, and not PP2Cβ alone, is specifically required for dephosphorylation of serine 366 on p53. Ectopic expression of GAS41 and PP2Cβ reduces UV radiation-induced p53 up-regulation, thereby increasing the cell survival upon genotoxic DNA damage. To our knowledge, the GAS41-PP2Cβ complex is the first example in which substrate specificity of a PP2C family member is controlled by an associated regulatory subunit. Because GAS41 is frequently amplified in human gliomas, our finding illustrates a novel oncogenic mechanism of GAS41 by p53 dephosphorylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.