ArticleApplied and environmental microbiology2011
Contribution of rapid evolution of the luxR-luxI intergenic region to the diverse bioluminescence outputs of Vibrio fischeri strains isolated from different environments.
Article in Applied and environmental microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 36 citations in OpenAlex.
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- Crosstalk enables mutual activation of coupled quorum sensing pathways through "jump-start" and "push-start" mechanisms.Scientific reports · 2023Article
- Quorum sensing facilitates interpopulation signaling byIsrael journal of chemistry · 2023Article
- Redesigning regulatory components of quorum-sensing system for diverse metabolic control.Nature communications · 2022Article
- Independent host- and bacterium-based determinants protect a model symbiosis from phage predation.Cell reports · 2022Article
- Activation of the Type VI Secretion System in the Squid SymbiontJournal of bacteriology · 2021Article
- Dimension-reduction simplifies the analysis of signal crosstalk in a bacterial quorum sensing pathway.Scientific reports · 2021Article
- A lasting symbiosis: how Vibrio fischeri finds a squid partner and persists within its natural host.Nature reviews. Microbiology · 2021Review
- Article
- Tools for Rapid Genetic Engineering of Vibrio fischeri.Applied and environmental microbiology · 2018Article
- Comparative analysis reveals regulatory motifs at the ainS/ainR pheromone-signaling locus of Vibrio fischeri.Scientific reports · 2017Article
- Intraspecific Competition Impacts Vibrio fischeri Strain Diversity during Initial Colonization of the Squid Light Organ.Applied and environmental microbiology · 2016Article
- Antisocial luxO Mutants Provide a Stationary-Phase Survival Advantage in Vibrio fischeri ES114.Journal of bacteriology · 2015Article
- Modeling Analysis of Signal Sensitivity and Specificity by Vibrio fischeri LuxR Variants.PloS one · 2015Article
- Social complementation and growth advantages promote socially defective bacterial isolates.Proceedings. Biological sciences · 2014Article
- Cyclic AMP receptor protein regulates pheromone-mediated bioluminescence at multiple levels in Vibrio fischeri ES114.Journal of bacteriology · 2013Article
- Substrate specificity and function of the pheromone receptor AinR in Vibrio fischeri ES114.Journal of bacteriology · 2013Article
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7 authors at 3 institutions in 1 country.
Funding
Abstract
Vibrio fischeri serves as a valuable model of bacterial bioluminescence, its regulation, and its functional significance. Light output varies more than 10,000-fold in wild-type isolates from different environments, yet dim and bright strains have similar organization of the light-producing lux genes, with the activator-encoding luxR divergently transcribed from luxICDABEG. By comparing the genomes of bright strain MJ11 and the dimmer ES114, we found that the lux region has diverged more than most shared orthologs, including those flanking lux. Divergence was particularly high in the intergenic sequence between luxR and luxI. Analysis of the intergenic lux region from 18 V. fischeri strains revealed that, with one exception, sequence divergence essentially mirrored strain phylogeny but with relatively high substitution rates. The bases conserved among intergenic luxR-luxI sequences included binding sites for known regulators, such as LuxR and ArcA, and bases of unknown significance, including a striking palindromic repeat. By using this collection of diverse luxR-luxI regions, we found that expression of P(luxI)-lacZ but not P(luxR)-lacZ transcriptional reporters correlated with the luminescence output of the strains from which the promoters originated. We also found that exchange of a small stretch of the luxI-luxR intergenic region between two strains largely reversed their relative brightness. Our results show that the luxR-luxI intergenic region contributes significantly to the variable luminescence output among V. fischeri strains isolated from different environments, although other elements of strain backgrounds also contribute. Moreover, the lux system appears to have evolved relatively rapidly, suggesting unknown environment-specific selective pressures.
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