Evidence map›Paper›PMID 21317242›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011

Combined impact of geriatric syndromes and cardiometabolic diseases on measures of functional impairment.

Andrea L Rosso, Charles B Eaton, Robert Wallace, Rachel Gold, J David Curb, Marcia L Stefanick, Judith K Ockene, Yvonne L Michael

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

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  8. [Cardiovascular aging].Zeitschrift fur Gerontologie und Geriatrie · 2011
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Andrea L RossoDepartment of Epidemiology and Biostatistics, School of Public Health, Drexel University, 1505 Race Street, Mail Stop 1033, Bellet 6th Floor, Philadelphia, PA 19102, USA. alr44@drexel.edu
Charles B Eaton
Robert Wallace
Rachel Gold
J David Curb
Marcia L Stefanick
Judith K Ockene
Yvonne L Michael
Drexel University · USKaiser Permanente Center for Health Research · USMemorial Hospital of Rhode Island · USStanford University · USUniversity of Hawaiʻi at Mānoa · USUniversity of Iowa · USUniversity of Massachusetts Chan Medical School · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
Women's Health Initiative Clinical Coordinating CenterN01WH22110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PRENTICE, ROSS L · 2007 to 2010
$22.5M
WOMENS HEALTH INITIATIVE-N01WH22110N01WH022110 · WH · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ROSS, PRENTICE · 1992 to 2006
$1.2M
Hormone therapy and change in functional status in Women's Health InitiativeR03AG031973 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI MICHAEL, YVONNE LOUISE · 2009 to 2010
$137k
NIA NIH HHS P30 AG024827NIA NIH HHS R03AG031973PHS HHS 24152PHS HHS 32100-2PHS HHS 32105-6PHS HHS 32108-9PHS HHS 32111-13PHS HHS 32115PHS HHS 32118-32119PHS HHS 32122PHS HHS 42107-26PHS HHS 42129-32PHS HHS 44221WHI NIH HHS N01 WH022110WHI NIH HHS N01WH22110
6 · The paper itself

Abstract

backgroundExamine the independent and joint effects of geriatric syndromes (GS) and cardiometabolic diseases (CMDs) on functional impairment.

methodsCross-sectional analysis of baseline data from the Women's Health Initiative, including 62,829 women aged 65 years or older. GS (urinary incontinence, falls, and depression measured by the shortened Center for Epidemiological Studies-Depression scale/Diagnostic Interview Schedule screening instrument) and CMD (coronary artery disease, coronary heart failure, and diabetes) were self-reported. Physical and social functioning and general health subscales of the Short Form-36 dichotomized at the median for the study sample were used to assess functional impairment. Additive interaction between burden of GS and CMD was assessed using logistic regression models.

resultsForty-three percent of women had at least one GS; 14.1% had at least one CMD; and 6.9% had at least one of each. Compared with women with no GS or CMD, women with one or more GS but no CMD were as likely to have physical functioning impairments (odds ratio [OR] = 1.79; 95% confidence interval [CI] = 1.73, 1.86) as those with CMD alone (OR = 1.97; CI = 1.84, 2.10). The association with social functioning was stronger for GS alone (OR = 2.10; CI = 2.02, 2.18) compared with CMD (OR = 1.60; CI = 1.50, 1.71). The association with general health was stronger for CMD alone (OR = 2.15; CI = 2.01, 2.29) compared with GS (OR = 1.68; CI = 1.62, 1.74). Significant interactions between GS and CMD were observed for all functional measures with 20%-30% of observed ORs attributable to additive interaction.

conclusionGSs alone are associated with functional impairment in older women; the association is stronger in the presence of even one CMD.

Indexed as

Accidental FallsAgedAgingCardiovascular DiseasesCognition DisordersCross-Sectional StudiesDepressionFemaleGeriatric AssessmentHumansMetabolic DiseasesUrinary Incontinence

Identifiers

PMID21317242
PMCPMC3041502
OpenAlexW2096071880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.