Trial reportThorax2011
UK Lung Screen (UKLS) nodule management protocol: modelling of a single screen randomised controlled trial of low-dose CT screening for lung cancer.
Trial report in Thorax, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
71 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impact of low-dose computed tomography (LDCT) screening on lung cancer-related mortality.The Cochrane database of systematic reviews · 2022Pooled it
- ESR/ERS white paper on lung cancer screening.European radiology · 2015Guideline
- From randomized trials to the clinic: is it time to implement individual lung-cancer screening in clinical practice? A multidisciplinary statement from French experts on behalf of the French intergroup (IFCT) and the groupe d'Oncologie de langue francaise (GOLF).Annals of oncology : official journal of the European Society for Medical Oncology · 2013Guideline
- Lung cancer screening with low-dose spiral computed tomography: evidence from a pooled analysis of two Italian randomized trials.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2017Trial
- Comparing the performance of trained radiographers against experienced radiologists in the UK lung cancer screening (UKLS) trial.The British journal of radiology · 2016Trial
- Trial
- Trial
- Lung Cancer Screening Using Low Dose CT Scanning in Germany. Extrapolation of results from the National Lung Screening Trial.Deutsches Arzteblatt international · 2015Trial
- Trial
- Randomized study on early detection of lung cancer with MSCT in Germany: study design and results of the first screening round.Journal of cancer research and clinical oncology · 2012Trial
- Dose exposure in the ITALUNG trial of lung cancer screening with low-dose CT.The British journal of radiology · 2012Trial
- Reduced lung-cancer mortality with low-dose computed tomographic screening.The New England journal of medicine · 2011Trial
- Recruitment strategies and outcomes in lung cancer screening programmes: a scoping review.European radiology · 2026Article
- Stage- and histology-specific sensitivity for the detection of lung cancer of the NELSON screening protocol-A modeling study.International journal of cancer · 2025Article
- Deep learning-based lung cancer risk assessment using chest computed tomography images without pulmonary nodules ≥8 mm.Translational lung cancer research · 2025Article
- Impact of single round of low dose CT lung cancer screening on cause of mortality in different socio-economic groups: a post-hoc analysis of long-term follow-up of the UKLS trial.The Lancet regional health. Europe · 2024Article
- Impact of deep learning image reconstruction on volumetric accuracy and image quality of pulmonary nodules with different morphologies in low-dose CT.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- Value of deep learning reconstruction of chest low-dose CT for image quality improvement and lung parenchyma assessment on lung window.European radiology · 2024Article
- Important parameters for cost-effective implementation of lung cancer screening.The British journal of radiology · 2023Review
- Selection of eligible participants for screening for lung cancer using primary care data.Thorax · 2022Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The UK Lung Screen (UKLS) is a randomised controlled trial of the use of low-dose multidetector CT for lung cancer screening. It completed the Health Technology Appraisal (HTA)-funded feasibility stage in October 2009 and the pilot UKLS will be initiated in early 2011. The pilot will randomise 4000 subjects to either low-dose CT screening or no screening. The full study, due to start in September 2012, if progression criteria are met, will randomise a further 28,000 subjects from seven centres in the UK. Subjects will be selected if they have sufficient risk of developing lung cancer according to the Liverpool Lung Project risk model. The UKLS employs the 'Wald Single Screen Design', which was modelled in the UKLS feasibility study. This paper describes the modelling of nodule management in UKLS by using volumetric analysis with a single initial screen design and follow-up period of 10 years. This modelling has resulted in the development and adoption of the UKLS care pathway, which will be implemented in the planned CT screening trial in the UK.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.