ArticleGenome biology and evolution2011
Lack of global dosage compensation in Schistosoma mansoni, a female-heterogametic parasite.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
57 citing papers in PubMed, 83 citations in OpenAlex.
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- The regulation of methylation on the Z chromosome and the identification of multiple novel Male Hyper-Methylated regions in the chicken.PLoS genetics · 2024Article
- Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows.PLoS genetics · 2023Article
- Searching for signatures of sexually antagonistic selection on stickleback sex chromosomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Dosage compensation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Shared evolutionary trajectories of three independent neo-sex chromosomes inGenome research · 2021Article
- Are Geckos Special in Sex Determination? Independently Evolved Differentiated ZZ/ZW Sex Chromosomes in Carphodactylid Geckos.Genome biology and evolution · 2021Article
- Detecting sex-linked genes using genotyped individuals sampled in natural populations.Genetics · 2021Article
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- Disagreement in FMolecular ecology resources · 2020Article
- Molecular and evolutionary dynamics of animal sex-chromosome turnover.Nature ecology & evolution · 2019Review
- How to identify sex chromosomes and their turnover.Molecular ecology · 2019Review
- Regional epigenetic differentiation of the Z Chromosome between sexes in a female heterogametic system.Genome research · 2019Article
- Dosage Compensation throughout the Schistosoma mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome.Genome biology and evolution · 2019Article
- Sex-Biased Gene Expression and Dosage Compensation on the Artemia franciscana Z-Chromosome.Genome biology and evolution · 2019Article
- Article
- Parent-of-Origin-Dependent Gene Expression in Male and Female Schistosome Parasites.Genome biology and evolution · 2018Article
- The deep conservation of the Lepidoptera Z chromosome suggests a non-canonical origin of the W.Nature communications · 2017Article
- Global Dosage Compensation Is Ubiquitous in Lepidoptera, but Counteracted by the Masculinization of the Z Chromosome.Molecular biology and evolution · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Many species have morphologically and genetically differentiated sex chromosomes, such as the XY pair of mammals. Y chromosomes are often highly degenerated and carry few functional genes, so that XY males have only one copy of most X-linked genes (whereas females have two). As a result, chromosome-wide mechanisms of dosage compensation, such as the mammalian X-inactivation, often evolve to reestablish expression balance. A similar phenomenon is expected in female-heterogametic species, where ZW females should suffer from imbalances due to W-chromosome degeneration. However, no global dosage compensation mechanisms have been detected in the two independent ZW systems that have been studied systematically (birds and silkworm), leading to the suggestion that lack of global dosage compensation may be a general feature of female-heterogametic species. However, analyses of other independently evolved ZW systems are required to test if this is the case. In this study, we use published genomic and expression data to test for the presence of global dosage compensation in Schistosoma mansoni, a trematode parasite that causes schistosomiasis in humans. We find that Z-linked expression is reduced relative to autosomal expression in females but not males, consistent with incomplete or localized dosage compensation. This gives further support to the theory that female-heterogametic species may not require global mechanisms of dosage compensation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.