ArticleMolecular and cellular neurosciences2011
Activity-dependent interactions of NSF and SNAP at living synapses.
Article in Molecular and cellular neurosciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling.Frontiers in molecular neuroscience · 2021Review
- Genetic analysis of the Drosophila ESCRT-III complex protein, VPS24, reveals a novel function in lysosome homeostasis.PloS one · 2021Article
- Robust CRISPR/Cas9-Mediated Tissue-Specific Mutagenesis Reveals Gene Redundancy and Perdurance inGenetics · 2019Article
- Cytokine exocytosis and JAK/STAT activation in theJournal of cell science · 2018Article
- Characterization of developmental and molecular factors underlying release heterogeneity ateLife · 2018Article
- Association of variants in microRNA with Parkinson's disease in Chinese Han population.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible.BMC genomics · 2017Article
- Association of Alpha-Soluble NSF Attachment Protein with Epileptic Seizure.Journal of molecular neuroscience : MN · 2015Article
- The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression.The Journal of biological chemistry · 2015Article
- The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Quercetin glycosides induced neuroprotection by changes in the gene expression in a cellular model of Parkinson's disease.Journal of molecular neuroscience : MN · 2015Article
- Recruitment of septin cytoskeletal proteins by botulinum toxin A protease determines its remarkable stability.Journal of cell science · 2014Article
- Spatiotemporal changes in NSF expression of DRG neurons in a rat model of spinal nerve ligation.Journal of molecular neuroscience : MN · 2014Article
- Molecular mechanisms of COMPLEXIN fusion clamp function in synaptic exocytosis revealed in a new Drosophila mutant.Molecular and cellular neurosciences · 2013Article
- The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF.The Journal of biological chemistryArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
As core components of the neurotransmitter release apparatus, SNAREs, NSF and SNAPs mediate fusion of neurotransmitter-filled synaptic vesicles within specialized regions of the presynaptic plasma membrane known as active zones (AZs). The present study combines genetic approaches in Drosophila with biochemical and live-imaging methods to provide new insights into the in vivo behavior and interactions of NSF and SNAP in neurotransmitter release. This work employs a temperature-sensitive (TS) paralytic NSF mutant, comatose, to show that disruption of NSF function results in activity-dependent redistribution of NSF and SNAP to periactive zone (PAZ) regions of the presynaptic plasma membrane and accumulation of protein complexes containing SNAREs, NSF and SNAP. Fluorescence Resonance Energy Transfer (FRET) and Fluorescence Recovery After Photobleaching (FRAP) studies in comatose revealed that NSF and SNAP exhibit activity-dependent binding to each other within living presynaptic terminals as well as distinctive interactions and mobilities. These observations extend current models describing the spatial organization of NSF, SNAP and SNARE proteins in synaptic vesicle trafficking.
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