ArticleNeuroscience letters2011
MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium.
Article in Neuroscience letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Noise induced epigenetic effects: A systematic review.Noise & healthPooled it
- miR-409-3p Regulates IFNG and p16 Signaling in the Human Blood of Aging-Related Hearing Loss.Cells · 2024Article
- miRNA and mRNA Profiling Links Connexin Deficiency to Deafness via Early Oxidative Damage in the MouseFrontiers in cell and developmental biology · 2020Article
- miR-149-5p Regulates Goat Hair Follicle Stem Cell Proliferation and Apoptosis by Targeting the CMTM3/AR Axis During Superior-Quality Brush Hair Formation.Frontiers in genetics · 2020Article
- Differential expression of miR-let7a in hair follicle cycle of Liaoning cashmere goats and identification of its targets.Functional & integrative genomics · 2018Article
- MicroRNAs and Presbycusis.Aging and disease · 2018Review
- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish.Yonsei medical journal · 2018Article
- Integrative analysis of the Pekin duck (Anas anas) MicroRNAome during feather follicle development.BMC developmental biology · 2017Article
- Insights into inner ear-specific gene regulation: Epigenetics and non-coding RNAs in inner ear development and regeneration.Seminars in cell & developmental biology · 2017Review
- Screening candidate microRNAs (miRNAs) in different lambskin hair follicles in Hu sheep.PloS one · 2017Article
- miR-124 promotes the neuronal differentiation of mouse inner ear neural stem cells.International journal of molecular medicine · 2016Article
- Next-generation sequencing of small RNAs from inner ear sensory epithelium identifies microRNAs and defines regulatory pathways.BMC genomics · 2014Article
- MicroRNAs in sensorineural diseases of the ear.Frontiers in molecular neuroscience · 2013Review
- Non-coding RNAs in the development of sensory organs and related diseases.Cellular and molecular life sciences : CMLS · 2013Review
- The Transcriptomics to Proteomics of Hair Cell Regeneration: Looking for a Hair Cell in a Haystack.Microarrays (Basel, Switzerland) · 2013Article
- Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss.PloS one · 2013Article
- The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.PloS one · 2013Article
- MicroRNAs in inner ear biology and pathogenesis.Hearing research · 2012Review
- Regeneration of Hair Cells: Making Sense of All the Noise.Pharmaceuticals (Basel, Switzerland) · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Specialized sensory-transducing hair cells regenerate in response to injury in non-mammalian vertebrates such as birds and fish but not in mammals. Previous work has shown that overexpression of microRNA181a (miR181a) in cultured chicken basilar papillae, the avian counterpart of the cochlea, is sufficient to stimulate proliferation with production of new hair cells. The present study investigates the role of miR181a in hair cell regeneration after injury in explants of chicken auditory epithelia. Basilar papillae were explanted from 0-day-old chickens and transfected with either anti-miR181a, which knocks down endogenous miR181a, or a non-targeting miRNA and cultured with streptomycin to eliminate all hair cells from the epithelium. Labeling with BrdU was used to quantify proliferation. Explants exposed to streptomycin and transfected with anti-miR181a had significantly fewer BrdU positive cells than basilar papillae treated with streptomycin and transfected with a non-targeting miRNA. Activated caspase-3 and myosin VI labeling were used to show that the pattern of hair cell death and loss, respectively, were not affected by anti-miR181a transfection. MiR181a downregulation therefore seems to dimish the proliferative component of hair cell regeneration rather than prevent hair cell death following ototoxic injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.