ArticleHormones and behavior2011
Estradiol effects on behavior and serum oxytocin are modified by social status and polymorphisms in the serotonin transporter gene in female rhesus monkeys.
Article in Hormones and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Endogenous oxytocin and human social interactions: A systematic review and meta-analysis.Psychological bulletinPooled it
- Social subordination produces distinct stress-related phenotypes in female rhesus monkeys.Psychoneuroendocrinology · 2012Trial
- Urinary Estradiol in Captive Bonobos: Variation With Reproductive State and Sexual Swelling.American journal of primatology · 2025Article
- Medial prefrontal glutamate response to acute stress is associated with social subordination in female rhesus macaques.Translational psychiatry · 2025Article
- Sex influences the effects of social status on socioemotional behavior and serotonin neurochemistry in rhesus monkeys.Biology of sex differences · 2023Article
- Oxytocin measurements in saliva: an analytical perspective.BMC veterinary research · 2023Review
- Behavioural and physiological plasticity in social hierarchies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Article
- Epigenetic prediction of 17β-estradiol and relationship to trauma-related outcomes in women.Comprehensive psychoneuroendocrinology · 2021Article
- Effects of social subordination and oestradiol on resting-state amygdala functional connectivity in adult female rhesus monkeys.Journal of neuroendocrinology · 2020Article
- Article
- Socially Housed Female Macaques: a Translational Model for the Interaction of Chronic Stress and Estrogen in Aging.Current psychiatry reports · 2017Review
- Relationships between steroid hormones in hair and social behaviour in ring-tailed lemurs (Lemur catta).Primates; journal of primatology · 2017Article
- Stress-induced alterations in estradiol sensitivity increase risk for obesity in women.Physiology & behavior · 2016Review
- Anger Emotional Stress Influences VEGF/VEGFR2 and Its Induced PI3K/AKT/mTOR Signaling Pathway.Neural plasticity · 2016Article
- A hidden reason for menopausal symptoms in premenopausal aged women: depression.International journal of clinical and experimental medicine · 2015Article
- Neural mechanisms of social dominance.Frontiers in neuroscience · 2015Review
- Stress, sex, and addiction: potential roles of corticotropin-releasing factor, oxytocin, and arginine-vasopressin.Behavioural pharmacology · 2014Review
- Stress and the reproductive axis.Journal of neuroendocrinology · 2014Review
- Oestradiol alters central 5-HT1A receptor binding potential differences related to psychosocial stress but not differences related to 5-HTTLPR genotype in female rhesus monkeys.Journal of neuroendocrinology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Despite the well-documented relation between estradiol (E2) and behavior, exposure to stressors may modify sensitivity to E2. The effects of E2 on behavior are, in part, likely related to their modulation of the serotonin (5HT) and oxytocin systems. The short allele (s-variant) polymorphism found in the promoter region of the SLC6A4 gene that encodes the 5HT transporter (5HTT) modulates responsivity to stressors. The current study used ovariectomized adult female rhesus monkeys to evaluate how exposure to the psychosocial stressor of social subordination and polymorphisms in the gene encoding 5HTT influence the behavioral effects of E2 and immunoreactive serum oxytocin. Dominant females had higher levels of oxytocin than subordinate animals even though E2 increased immunoreactive serum oxytocin in all females. E2 increased affiliative behaviors in all animals, with even more of these prosocial behaviors directed at dominant females. S-variant females, regardless of social status, were more aggressive toward more subordinate cage mates and these behaviors too were increased by E2. Subordinate s-variant females are most often involved in agonistic behavior, less affiliative behavior, and were less responsive to the anxiolytic action of E2. The results show that the short allele of the 5HTT gene synergizes with psychosocial stress exposure to affect the behavioral efficacy of E2 while confirming the actions of E2 for producing generalized behavioral arousal in females. Whether differences in the central action of 5HT and/or oxytocin are responsible for this effect requires further study.
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