ArticleArchives of oral biology2011
Regulation of antimicrobial peptide expression in human gingival keratinocytes by interleukin-1α.
Article in Archives of oral biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Characterization of a human skin equivalent model to study the effects of ultraviolet B radiation on keratinocytes.Tissue engineering. Part C, Methods · 2014Trial
- Emerging therapeutic strategies targeting bone signaling pathways in periodontitis.Journal of periodontal research · 2025Review
- Synthesis of secretory leukocyte protease inhibitor using cell-free protein synthesis system.Odontology · 2024Article
- Article
- Adrenomedullin: Not Just Another Gastrointestinal Peptide.Biomolecules · 2022Review
- Antimicrobial peptides: Defending the mucosal epithelial barrier.Frontiers in oral health · 2022Review
- Mesenchymal Stem Cell-Derived Antimicrobial Peptides as Potential Anti-Neoplastic Agents: New Insight into Anticancer Mechanisms of Stem Cells and Exosomes.Frontiers in cell and developmental biology · 2022Review
- [Expression and distribution of calprotectin in healthy and inflamed periodontal tissues].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2021Article
- Compromised dental cells viability following teeth-whitening exposure.Scientific reports · 2021Article
- Periodontitis and oral cancer - current concepts of the etiopathogenesis.Oncology reviews · 2020Article
- Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues.Journal of clinical medicine · 2019Review
- Intestinal manipulation affects mucosal antimicrobial defense in a mouse model of postoperative ileus.PloS one · 2018Article
- S100A8/A9 and S100A9 reduce acute lung injury.Immunology and cell biology · 2017Article
- Autonomous immunity in mucosal epithelial cells: fortifying the barrier against infection.Microbes and infection · 2016Review
- Effect of Hangeshashinto on calprotectin expression in human oral epithelial cells.Odontology · 2016Article
- Hydrogen peroxide-induced apoptosis in human gingival fibroblasts.International journal of clinical and experimental pathology · 2015Article
- Mechanism of interleukin-1α transcriptional regulation of S100A9 in a human epidermal keratinocyte cell line.Biochimica et biophysica acta · 2013Article
- Amyloid-β peptide-induced extracellular S100A9 depletion is associated with decrease of antimicrobial peptide activity in human THP-1 monocytes.Journal of neuroinflammation · 2013Article
- Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children.BMC infectious diseases · 2011Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
In the oral cavity, mucosal keratinocytes resist bacterial infection, in part, by producing broad-spectrum antimicrobial peptides (AMPs) including defensin, adrenomedullin and calprotectin. Epidermal keratinocyte expression of many AMPs increases in response to interleukin-1α (IL-1α). IL-1α is produced by epidermal keratinocytes and regulates cell differentiation. To better understand innate immunity in the oral cavity, we sought to determine how IL-1α might regulate expression of AMPs by human gingival keratinocytes (HGKs) using DNA microarray and Western blot analyses. HGKs from three subjects expressed eleven AMPs, including S100A7, S100A8, S100A9, S100A12, secretory leucocyte protease inhibitor, lipocalin 2 (LCN2), cystatin C and β-defensin 2. Of the expressed AMPs, S100A7, S100A12 and LCN2 were up-regulated by IL-1α (inducible AMPs); the other AMPs were considered to be constitutive. Human gingival keratinocytes, therefore, express constitutive and IL-1α-inducible AMPs to provide a rapid and robust innate response to microbial infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.