ArticleGastroenterology2011
The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells.
Article in Gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Xenopus laevis Egg Extracts.Methods in molecular biology (Clifton, N.J.) · 2026Article
- The nuclear pore Y-complex functions as a platform for transcriptional regulation of FLOWERING LOCUS C in Arabidopsis.The Plant cell · 2024Article
- You are who your friends are-nuclear pore proteins as components of chromatin-binding complexes.FEBS letters · 2023Review
- FGF-2 induces a failure of cell cycle progression in cells harboring amplified K-Ras, revealing new insights into oncogene-induced senescence.Molecular omics · 2021Article
- Mapping the micro-proteome of the nuclear lamina and lamina-associated domains.Life science alliance · 2021Article
- Nuclear pore complexes in development and tissue homeostasis.Development (Cambridge, England) · 2020Review
- Article
- Enhancer functions in three dimensions: beyond the flat world perspective.F1000Research · 2018Review
- The roles of the nuclear pore complex in cellular dysfunction, aging and disease.Seminars in cell & developmental biology · 2017Review
- Identification of Conserved MEL-28/ELYS Domains with Essential Roles in Nuclear Assembly and Chromosome Segregation.PLoS genetics · 2016Article
- Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche.Development (Cambridge, England) · 2015Article
- Nuclear pore proteins and the control of genome functions.Genes & development · 2015Review
- CDC42 inhibition suppresses progression of incipient intestinal tumors.Cancer research · 2014Article
- Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition.Cell cycle (Georgetown, Tex.) · 2014Article
- Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos.The Journal of biological chemistry · 2012Article
- Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.Nucleic acids research · 2012Article
- Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.The Journal of clinical investigation · 2012Article
- The nuclear envelope environment and its cancer connections.Nature reviews. Cancer · 2012Review
- The spindle assembly checkpoint: More than just keeping track of the spindle.Trends in cell & molecular biologyArticle
- Characterization of nuclear pore complex components in fission yeast Schizosaccharomyces pombe.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND &
aimsElys is a conserved protein that directs nuclear pore complex (NPC) assembly in mammalian cell lines and developing worms and zebrafish. Related studies in these systems indicate a role for Elys in DNA replication and repair. Intestinal epithelial progenitors of zebrafish elys mutants undergo apoptosis early in development. However, it is not known whether loss of Elys has a similar effect in the mammalian intestine or whether the NPC and DNA repair defects each contribute to the overall phenotype.
methodsWe developed mice in which a conditional Elys allele was inactivated in the developing intestinal epithelium and during preimplantation development. Phenotypes of conditional mutant mice were determined using immunohistochemical analysis for nuclear pore proteins, electron microscopy, and immunoblot analysis of DNA replication and repair proteins.
resultsConditional inactivation of the Elys locus in the developing mouse intestinal epithelium led to a reversible delay in growth in juvenile mice that was associated with epithelial architecture distortion and crypt cell apoptosis. The phenotype was reduced in adult mutant mice, which were otherwise indistinguishable from wild-type mice. All mice had activated DNA damage responses but no evidence of NPC assembly defects.
conclusionsIn mice, Elys maintains genome stability in intestinal epithelial progenitor cells, independent of its role in NPC assembly in zebrafish.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.