ArticleVaccine2011
Generation of Salmonella-specific Th1 cells requires sustained antigen stimulation.
Article in Vaccine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Comparative evaluation of the immunogenicity and protective efficacy of gamma-irradiated Salmonella Gallinarum (γ-SG), SG ΔpurB mutant, and their combined vaccine formulations in chicken.Microbial pathogenesis · 2026Article
- Evaluation of immunogenicity and protective efficacy of Salmonella Gallinarum knockout purB mutant strain in chicken.Veterinary research communications · 2026Article
- Salmonella-superspreader hosts require gut regulatory T cells to maintain a disease-tolerant state.The Journal of experimental medicine · 2025Article
- Article
- Vaccine-induced inflammation and inflammatory monocytes promote CD4+ T cell-dependent immunity against murine salmonellosis.PLoS pathogens · 2023Article
- Antibiotic Treatment of Staphylococcus aureus Infection Inhibits the Development of Protective Immunity.Antimicrobial agents and chemotherapy · 2022Article
- Tissue specificity drives protective immunity againstFrontiers in immunology · 2022Article
- Regulation of Th1 T Cell Differentiation by IronFrontiers in immunology · 2021Article
- Early programming and late-acting checkpoints governing the development of CD4 T-cell memory.Immunology · 2018Review
- Diet-induced obese mice exhibit altered immune responses to early Salmonella Typhimurium oral infection.Journal of microbiology (Seoul, Korea) · 2018Article
- Dual Immunization with SseB/Flagellin Provides Enhanced Protection againstJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Two NovelFrontiers in cellular and infection microbiology · 2017Article
- Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory.mBio · 2016Review
- Immunity to intestinal pathogens: lessons learned from Salmonella.Immunological reviews · 2014Review
- The Role of Non-Cognate T Cell Stimulation during Intracellular Bacterial Infection.Frontiers in immunology · 2014Review
- Article
- MHC class-I-restricted CD8 T cells play a protective role during primary Salmonella infection.Immunology letters · 2012Article
- Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development.PLoS pathogens · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The administration of live attenuated Salmonella strains has proven to be an effective way to generate protective immunity against Salmonella infection in humans and mice. Studies in the mouse model have shown that protection requires Salmonella-specific Th1 cells, however the timing and stimulatory requirements for generating optimal Th1 responses have not been carefully examined. We used antibiotic interruption of vaccination with live attenuated Salmonella to examine the requirements for Salmonella-specific Th1 development and protective immunity. Optimal development of protective immunity to Salmonella infection required at least one week of exposure to the live attenuated Salmonella strain. In contrast, optimal development of Salmonella-specific Th1 cells required two weeks of in vivo colonization. Thus, sustained in vivo stimulation with a live vaccine strain is essential for the development of robust Salmonella-specific Th1 cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.