ArticleVeterinary research2011
Breeding with resistant rams leads to rapid control of classical scrapie in affected sheep flocks.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Space-time distribution of classical scrapie in Italian sheep: assessing the effectiveness of the National Genetic Selection Plan.Veterinary research · 2025Article
- Review
- Predicted breeding values for relative scrapie susceptibility for genotyped and ungenotyped sheep.Genetics, selection, evolution : GSE · 2024Article
- Article
- Chronic wasting disease in Europe: new strains on the horizon.Acta veterinaria Scandinavica · 2021Review
- White-tailed deer S96 prion protein does not support stable in vitro propagation of most common CWD strains.Scientific reports · 2021Article
- Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis.International journal of molecular sciences · 2021Review
- Prion protein polymorphisms associated with reduced CWD susceptibility limit peripheral PrPBMC veterinary research · 2019Article
- Estimating relative CWD susceptibility and disease progression in farmed white-tailed deer with rare PRNP alleles.PloS one · 2019Article
- Association between combinations of genetic polymorphisms and epidemiopathogenic forms of bovine paratuberculosis.Heliyon · 2018Article
- Modelling of strategies for genetic control of scrapie in sheep: The importance of population structure.PloS one · 2018Article
- Article
- Scrapie incidence and PRNP polymorphisms: rare small ruminant breeds of Sicily with TSE protecting genetic reservoirs.BMC veterinary research · 2016Article
- Antemortem Detection of Chronic Wasting Disease Prions in Nasal Brush Collections and Rectal Biopsy Specimens from White-Tailed Deer by Real-Time Quaking-Induced Conversion.Journal of clinical microbiology · 2016Article
- Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats.BMC veterinary research · 2016Article
- Article
- Prion protein genotypes of sheep as determined from 3343 samples submitted from Ontario and other provinces of Canada from 2005 to 2012.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2014Article
- Detection of chronic wasting disease in the lymph nodes of free-ranging cervids by real-time quaking-induced conversion.Journal of clinical microbiology · 2014Article
- Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats.Veterinary research · 2014Article
- Genetic resistance to scrapie infection in experimentally challenged goats.Journal of virology · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility to scrapie, a transmissible spongiform encephalopathy in sheep, is modulated by the genetic make-up of the sheep. Scrapie control policies, based on selecting animals of resistant genotype for breeding, have recently been adopted by the Netherlands and other European countries. Here we assess the effectiveness of a breeding programme based on selecting rams of resistant genotype to obtain outbreak control in classical scrapie-affected sheep flocks under field conditions. In six commercially-run flocks following this breeding strategy, we used genotyping to monitor the genotype distribution, and tonsil biopsies and post-mortem analyses to monitor the occurrence of scrapie infection. The farmers were not informed about the monitoring results until the end of the study period of six years. We used a mathematical model of scrapie transmission to analyze the monitoring data and found that where the breeding scheme was consistently applied, outbreak control was obtained after at most four years. Our results also show that classical scrapie control can be obtained before the frequency of non-resistant animals is reduced to zero in the flock. This suggests that control at the national scale can be obtained without a loss of genetic polymorphisms from any of the sheep breeds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.