Evidence map›Paper›PMID 21314933›Full record

ArticleBMC infectious diseases2011

Antibodies against Coxiella burnetii and pregnancy outcome during the 2007-2008 Q fever outbreaks in The Netherlands.

Wim van der Hoek, Jamie C E Meekelenkamp, Alexander C A P Leenders, Nancy Wijers, Daan W Notermans, Chantal W P M Hukkelhoven

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Evidence ofNew microbes and new infections · 2025
    Review
  4. Q Fever-A Neglected Zoonosis.Microorganisms · 2022
    Review
  5. Serological Prevalence of and Risk Factors forInternational journal of environmental research and public health · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Antimicrobial therapies for Q fever.Expert review of anti-infective therapy · 2013
    Review
  19. Q fever and pregnancy: disease, prevention, and strain specificity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Wim van der HoekCentre for Infectious Disease Control, National Institute for Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands. wim.van.der.hoek@rivm.nl
Jamie C E Meekelenkamp
Alexander C A P Leenders
Nancy Wijers
Daan W Notermans
Chantal W P M Hukkelhoven
National Institute for Public Health and the Environment · NLJeroen Bosch Ziekenhuis · NLDutch Heart Registry · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundQ fever has become a major public health problem in The Netherlands. Infection with Coxiella burnetii (Q fever) during pregnancy has resulted in adverse pregnancy outcome in the majority of reported cases. Therefore, we aimed to quantify this risk by examining the earliest periods corresponding to the epidemic in The Netherlands.

methodsSerum samples that had been collected from the area of highest incidence by an existing national prenatal screening programme and data from the Netherlands Perinatal Registry (PRN) on diagnosis and outcome were used. We performed indirect immunofluorescence assay to detect the presence of IgM and IgG antibodies against C. burnetii in the samples. The serological results were analyzed to determine statistical association with recorded pregnancy outcome.

resultsEvaluation of serological results for 1174 women in the PRN indicated that the presence of IgM and IgG antibodies against phase II of C. burnetii was not significantly associated with preterm delivery, low birth weight, or several other outcome measures.

conclusionThe present population-based study showed no evidence of adverse pregnancy outcome among women who had antibodies to C. burnetii during early pregnancy.

Indexed as

Pregnancy OutcomeAdultAntibodies, BacterialCoxiella burnetiiDisease OutbreaksFemaleHumansMaleNetherlandsPregnancyPregnancy Complications, InfectiousQ FeverAntibodies, Bacterial

Identifiers

PMID21314933
PMCPMC3042933
OpenAlexW2077274617

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.