ReviewCurrent topics in behavioral neurosciences2010
Eye tracking dysfunction in schizophrenia: characterization and pathophysiology.
Review in Current topics in behavioral neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
73 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacodynamic Interactions Between Ketamine and Psychiatric Medications Used in the Treatment of Depression: A Systematic Review.The international journal of neuropsychopharmacology · 2021Pooled it
- Effects of nicotine on smooth pursuit eye movements in healthy non-smokers.Psychopharmacology · 2019Trial
- Effects of ketamine on brain function during smooth pursuit eye movements.Human brain mapping · 2016Trial
- The effects of ketamine and risperidone on eye movement control in healthy volunteers.Translational psychiatry · 2013Trial
- Effects of risperidone, amisulpride and nicotine on eye movement control and their modulation by schizotypy.Psychopharmacology · 2013Trial
- Fixation Task: A Simple Eye Movement Task Reveals an Impairment in Schizophrenia.Schizophrenia bulletin · 2026Article
- Preserved contextual modulation of eye movements in psychosis prone individuals.Journal of vision · 2026Article
- Identifying an oculomotor phenotype for adolescent depression with an interleaved pro- and anti-saccade task.Frontiers in psychiatry · 2026Article
- Schizophrenia Pathophysiology: Neurotransmitter Dysfunctions and Biomarker Frontiers.Current topics in medicinal chemistry · 2026Review
- Bistable Perception Discriminates Between Depressive Patients, Controls, Schizophrenia Patients, and Their Siblings.Schizophrenia bulletin · 2025Article
- Assessing Smooth Pursuit Eye Movements Using Eye-Tracking Technology in Patients with Schizophrenia Under Treatment: A Pilot Study.Sensors (Basel, Switzerland) · 2025Article
- Abnormal eye movement, brain regional homogeneity in schizophrenia and clinical high-risk individuals and their associated gene expression profiles.Schizophrenia (Heidelberg, Germany) · 2025Article
- Abnormalities in cognitive-related functional connectivity can be used to identify patients with schizophrenia and individuals in clinical high-risk.BMC psychiatry · 2025Article
- Eye Movement Characteristics for Predicting a Transition to Psychosis: Longitudinal Changes and Implications.Schizophrenia bulletin · 2025Observational
- Reduced Visual Function in Schizotypal Traits: An Exploratory Study.Schizophrenia bulletin · 2025Article
- Metrics of two-dimensional smooth pursuit are diverse across participants and stable across days.Journal of vision · 2025Article
- Scanpath EEG dynamic, a new perspective for neuroaesthetic connoisseurship in paintings.Frontiers in psychology · 2025Review
- Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis.Scientific reports · 2024Article
- Transcriptional control of visual neural circuit development by GS homeobox 1.PLoS genetics · 2024Article
- The role of torso stiffness and prediction in the biomechanics of anxiety: a narrative review.Frontiers in sports and active living · 2024Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Eye tracking dysfunction (ETD) is one of the most widely replicated behavioral deficits in schizophrenia and is over-represented in clinically unaffected first-degree relatives of schizophrenia patients. Here, we provide an overview of research relevant to the characterization and pathophysiology of this impairment. Deficits are most robust in the maintenance phase of pursuit, particularly during the tracking of predictable target movement. Impairments are also found in pursuit initiation and correlate with performance on tests of motion processing, implicating early sensory processing of motion signals. Taken together, the evidence suggests that ETD involves higher-order structures, including the frontal eye fields, which adjust the gain of the pursuit response to visual and anticipated target movement, as well as early parts of the pursuit pathway, including motion areas (the middle temporal area and the adjacent medial superior temporal area). Broader application of localizing behavioral paradigms in patient and family studies would be advantageous for refining the eye tracking phenotype for genetic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.