ArticleDevelopmental neurobiology2012
Vision drives correlated activity without patterned spontaneous activity in developing Xenopus retina.
Article in Developmental neurobiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Premature vision drives aberrant development of response properties in primary visual cortex.eLife · 2025Article
- Premature vision drives aberrant development of response properties in primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Hebbian instruction of axonal connectivity by endogenous correlated spontaneous activity.Science (New York, N.Y.) · 2024Article
- Ocular Necessities: A Neuroethological Perspective on Vertebrate Visual Development.Brain, behavior and evolution · 2024Review
- BDNF signaling in correlation-dependent structural plasticity in the developing visual system.PLoS biology · 2023Article
- An Algorithm Based on a Cable-Nernst Planck Model Predicting Synaptic Activity throughout the Dendritic Arbor with Micron Specificity.Neuroinformatics · 2023Article
- Topographic map formation and the effects of NMDA receptor blockade in the developing visual system.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina.Cell reports · 2022Article
- Müller Glia in Retinal Development: From Specification to Circuit Integration.Frontiers in neural circuits · 2021Review
- Background choice and immobility as context dependent tadpole responses to perceived predation risk.Scientific reports · 2020Article
- A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Waves.Current biology : CB · 2019Article
- Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors.Nature communications · 2016Article
- Emergence of Selectivity to Looming Stimuli in a Spiking Network Model of the Optic Tectum.Frontiers in neural circuits · 2016Article
- An Evolutionarily Conserved Mechanism for Activity-Dependent Visual Circuit Development.Frontiers in neural circuits · 2016Review
- Glutamatergic Retinal Waves.Frontiers in neural circuits · 2016Review
- Rules for Shaping Neural Connections in the Developing Brain.Frontiers in neural circuits · 2016Review
- Role of emergent neural activity in visual map development.Current opinion in neurobiology · 2014Review
- Review
- Global hyper-synchronous spontaneous activity in the developing optic tectum.Scientific reports · 2013Article
- Visual map development depends on the temporal pattern of binocular activity in mice.Nature neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Developing amphibians need vision to avoid predators and locate food before visual system circuits fully mature. Xenopus tadpoles can respond to visual stimuli as soon as retinal ganglion cells (RGCs) innervate the brain, however, in mammals, chicks and turtles, RGCs reach their central targets many days, or even weeks, before their retinas are capable of vision. In the absence of vision, activity-dependent refinement in these amniote species is mediated by waves of spontaneous activity that periodically spread across the retina, correlating the firing of action potentials in neighboring RGCs. Theory suggests that retinorecipient neurons in the brain use patterned RGC activity to sharpen the retinotopy first established by genetic cues. We find that in both wild type and albino Xenopus tadpoles, RGCs are spontaneously active at all stages of tadpole development studied, but their population activity never coalesces into waves. Even at the earliest stages recorded, visual stimulation dominates over spontaneous activity and can generate patterns of RGC activity similar to the locally correlated spontaneous activity observed in amniotes. In addition, we show that blocking AMPA and NMDA type glutamate receptors significantly decreases spontaneous activity in young Xenopus retina, but that blocking GABA(A) receptor blockers does not. Our findings indicate that vision drives correlated activity required for topographic map formation. They further suggest that developing retinal circuits in the two major subdivisions of tetrapods, amphibians and amniotes, evolved different strategies to supply appropriately patterned RGC activity to drive visual circuit refinement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.