ReviewDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Facultative stem cells in liver and pancreas: fact and fancy.
Review in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Rbpj deletion in hepatic progenitor cells attenuates endothelial responses and fibrosis in DDC-fed mice.Hepatology communications · 2025Article
- Lineage plasticity and reprogramming of epithelial cells during tissue injury and regeneration-lessons from the lineage plasticity of hepatocytes and cholangiocytes induced by liver injury.Regenerative therapy · 2025Review
- The molecular determinants of phenotypic plasticity in homeostasis and neoplasia.Cancer heterogeneity and plasticity · 2024Article
- Infantile hemangioma models: is the needle in a haystack?Journal of translational medicine · 2023Review
- Article
- Characteristics of SOX9-positive progenitor-like cells during cholestatic liver regeneration in biliary atresia.Stem cell research & therapy · 2022Article
- Review
- Review
- Adult Pancreatic Acinar Progenitor-like Populations in Regeneration and Cancer.Trends in molecular medicine · 2020Review
- Spatial heterogeneity in the mammalian liver.Nature reviews. Gastroenterology & hepatology · 2019Review
- p53 on the crossroad between regeneration and cancer.Cell death and differentiation · 2017Review
- Dclk1 Defines Quiescent Pancreatic Progenitors that Promote Injury-Induced Regeneration and Tumorigenesis.Cell stem cell · 2016Article
- Snoo and Dpp Act as Spatial and Temporal Regulators Respectively of Adult Progenitor Cells in the Drosophila Trachea.PLoS genetics · 2016Article
- Stem cells versus plasticity in liver and pancreas regeneration.Nature cell biology · 2016Review
- Development and application of human adult stem or progenitor cell organoids.Nature reviews. Nephrology · 2015Review
- Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung.Nature communications · 2015Article
- Cellular homeostasis and repair in the mammalian liver.Annual review of physiology · 2015Review
- Glucose transporter 1-positive endothelial cells in infantile hemangioma exhibit features of facultative stem cells.Stem cells (Dayton, Ohio) · 2015Article
- Adult hepatocytes are generated by self-duplication rather than stem cell differentiation.Cell stem cell · 2014Article
- Mesodermal mesenchymal cells give rise to myofibroblasts, but not epithelial cells, in mouse liver injury.Hepatology (Baltimore, Md.) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Tissue turnover is a regular feature of higher eukaryotes, either as part of normal wear and tear (homeostasis) or in response to injury (regeneration). Cell replacement is achieved either through replication of existing cells or differentiation from a self-renewing pool of stem cells. The major distinction regards cellular potential, because stem cells by definition have a capacity to differentiate, while replication implies that cells adopt a single fate under physiologic conditions. A hybrid model, the facultative stem cell (FSC) model, posits that tissues contain cells that normally exhibit unipotency but have the capacity to function as stem cells upon injury. The FSC paradigm is well established in urodele amphibians, but the nature and role of FSCs in mammals is less defined. Here, we review the evidence for FSCs in two mammalian organs, the liver and the pancreas, and discuss alternative models that could account for regeneration in these organs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.