ArticleTransgenic research2011
Lysozyme transgenic goats' milk positively impacts intestinal cytokine expression and morphology.
Article in Transgenic research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Trial
- Immunomodulatory Role of Milk on Gut Microbiota: Implications for Enhancing Oral Vaccine Efficacy.Probiotics and antimicrobial proteins · 2026Review
- Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides.Foods (Basel, Switzerland) · 2024Review
- Effects of Dietary Microbial Muramidase on the Growth, Liver Histoarchitecture, Antioxidant Status, and Immunoexpression of Pro-Inflammatory Cytokines in Broiler Chickens.Animals : an open access journal from MDPI · 2023Article
- Dietary lysozyme improves growth performance and intestinal barrier function of weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Exploring the effects of lysozyme dietary supplementation on laying hens: performance, egg quality, and immune response.Frontiers in veterinary science · 2023Article
- Effects of dietary lysozyme supplementation on growth performance, nutrient digestibility, intestinal microbiota, and blood profiles of weanling pigs challenged withJournal of animal science and technology · 2021Article
- Large-scale production of functional human lysozyme from marker-free transgenic cloned cows.Scientific reports · 2016Article
- Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: past, present, and future.Transgenic research · 2015Review
- Generation of bi-transgenic pigs overexpressing human lactoferrin and lysozyme in milk.Transgenic research · 2015Article
- Lysozyme as an alternative to growth promoting antibiotics in swine production.Journal of animal science and biotechnology · 2015Article
- Production of transgenic-cloned pigs expressing large quantities of recombinant human lysozyme in milk.PloS one · 2015Article
- Assessing unintended effects of a mammary-specific transgene at the whole animal level in host and non-target animals.Transgenic research · 2014Article
- Article
- Consumption of transgenic cows' milk containing human lactoferrin results in beneficial changes in the gastrointestinal tract and systemic health of young pigs.Transgenic research · 2013Article
- Consuming transgenic goats' milk containing the antimicrobial protein lysozyme helps resolve diarrhea in young pigs.PloS one · 2013Article
- MiR-103 controls milk fat accumulation in goat (Capra hircus) mammary gland during lactation.PloS one · 2013Article
- Transgenesis applied to goat: current applications and ongoing research.Transgenic research · 2012Review
- Consumption of lysozyme-rich milk can alter microbial fecal populations.Applied and environmental microbiology · 2012Article
- Goat milk with and without increased concentrations of lysozyme improves repair of intestinal cell damage induced by enteroaggregative Escherichia coli.BMC gastroenterology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to its well-recognized antimicrobial properties, lysozyme can also modulate the inflammatory response. This ability may be particularly important in the gastrointestinal tract where inappropriate inflammatory reactions can damage the intestinal epithelium, leading to significant health problems. The consumption of milk from transgenic goats producing human lysozyme (hLZ) in their milk therefore has the potential to positively impact intestinal health. In order to investigate the effect of hLZ-containing milk on the inflammatory response, young pigs were fed pasteurized milk from hLZ or non-transgenic control goats and quantitative real-time PCR was performed to assess local expression of TNF-α, IL-8, and TGF-β1 in the small intestine. Histological changes were also investigated, specifically looking at villi width, length, crypt depth, and lamina propria thickness along with cell counts for intraepithelial lymphocytes and goblet cells. Significantly higher expression of anti-inflammatory cytokine TGF-β1 was seen in the ileum of pigs fed pasteurized milk containing hLZ (P = 0.0478), along with an increase in intraepithelial lymphocytes (P = 0.0255), and decrease in lamina propria thickness in the duodenum (P = 0.0001). Based on these results we conclude that consuming pasteurized milk containing hLZ does not induce an inflammatory response and improves the health of the small intestine in pigs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.