ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2011
The effect of Lidocaine on the viability of cultivated mature human cartilage cells: an in vitro study.
Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up.Clinics (Sao Paulo, Brazil) · 2022Trial
- Adverse events associated with local anaesthetic use in musculoskeletal injection therapy: a scoping review.BMJ open sport & exercise medicine · 2026Article
- Lidocaine Shows Significant Antimicrobial Effects AgainstBiomedicines · 2025Article
- Polymeric Nanocapsules Loaded with Lidocaine: A Promising Formulation for Topical Dental Anesthesia.Pharmaceuticals (Basel, Switzerland) · 2024Article
- FactFinders for patient safety: Preventing local anesthetic-related complications: Local anesthetic chondrotoxicity and stellate ganglion blocks.Interventional pain medicine · 2023Article
- Promising potential of articaine-loaded poly(epsilon-caprolactone) nanocapules for intraoral topical anesthesia.PloS one · 2021Article
- Narrative review: the evidence for neurotoxicity of dental local anesthetics.Journal of dental anesthesia and pain medicine · 2020Review
- Local Anesthetics' Toxicity toward Human Cultured Chondrocytes: A Comparative Study between Lidocaine, Bupivacaine, and Ropivacaine.Cartilage · 2019Article
- Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings.The veterinary quarterly · 2018Article
- Protective effects of platelet-rich plasma against lidocaine cytotoxicity on canine articular chondrocytes.Acta veterinaria Scandinavica · 2018Article
- Procaine and saline have similar effects on articular cartilage and synovium in rat knee.BMC anesthesiology · 2018Article
- Articular cartilage and local anaesthetic: A systematic review of the current literature.Journal of orthopaedics · 2015Article
- An evaluation of the delayed effect of intra-articular injections of lidocaine (2%) on articular cartilage: an experimental study in rabbits.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2014Article
- Comparison of ropivacaine and fentanyl toxicity in human fibroblasts.Archives of medical science : AMS · 2013Article
- The effect of local anaesthetics on synoviocytes: a possible indirect mechanism of chondrolysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2013Article
- Wrist Arthroscopy under Portal Site Local Anesthesia (PSLA) without Tourniquet.Journal of wrist surgery · 2012Article
- Local anaesthetics and chondrotoxicty: What is the evidence?Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Review
- The effect of local anesthetic and corticosteroid combinations on chondrocyte viability.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2012Article
- The effects of lidocaine and procaine on microRNA expression of adipocyte-derived adult stem cells.Korean journal of anesthesiology · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMore and more orthopedic procedures are performed in an outpatient setting. A commonly used strategy in pain management is the intra-articular injection of local anesthetics. Recent attention has been drawn to their possible toxic effect on chondrocytes. Local anesthetics, and in particular Lidocaine, are also used for diagnostic joint infiltrations. A controlled laboratory study was performed to investigate the possible toxic effect of Lidocaine on human articular chondrocytes.
methodsMature human articular chondrocytes were harvested from the knees of human tissue donors or patients undergoing total knee replacement. The cells were exposed to Lidocaine 1 and 2% with and without epinephrine and to a saline 0.9% control group, with variable exposure times in different experiments. The activity and viability of the cells were assessed by lactate dehydrogenase activity, interleukin-6 production and a live/dead cell count.
resultsAfter a 1-h exposure, devastating results were seen for Lidocaine 1, 2 and 2% with epinephrine showing cell death rates of 91, 99 and 97%, respectively, compared with 26% in the saline control group (P-values of 0.004, 0.010, 0.006, respectively). Exposing the chondrocytes to a 50/50 mixture of culture medium and local anesthetics substantially decreased cytotoxicity but still showed high toxicity when compared with the saline group (90% dead cells for Lidocaine 2%, P = 0.047). Lidocaine also showed a time-dependent cytotoxicity with gradually more dead cells after exposure for 15, 30 or 60 min.
conclusionIn vitro, local anesthetics containing Lidocaine are significantly more toxic to mature human articular chondrocytes than a saline 0.9% control group. The effect of Lidocaine on the viability of human chondrocytes in vivo needs further investigation. However, based on our in vitro results, cautious use of intra-articular Lidocaine in clinical practice is recommended.
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Registered trials
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