ArticleObesity (Silver Spring, Md.)2011
Bone age advancement in prepubertal children with obesity and premature adrenarche: possible potentiating factors.
Article in Obesity (Silver Spring, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- GrowthHormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome.The Journal of clinical endocrinology and metabolism · 2013Pooled it
- The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9-11 Years: The Physical Activity and Nutrition in Children Study.Frontiers in endocrinology · 2022Trial
- Determinants of Advanced Bone Age in Childhood Obesity .Hormone research in paediatrics · 2017Trial
- Insulin levels in prepubertal patients with isolated premature pubarche: TheClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026Article
- Determinants of pubertal progression and final height in premature pubarche.Journal of endocrinological investigation · 2026Article
- Genotype-refined 17OHP cut-offs diagnosing nonclassical CAH due to 21OH deficiency in children with premature pubarche.Journal of the Endocrine Society · 2026Article
- Correlation of body mass index and serum 25-hydroxyvitamin D levels with advanced bone age in children from northwest China: a cross-sectional study.Translational pediatrics · 2026Article
- Bone age evaluation in an ethnically diverse cohort of children with premature adrenarche.Pediatric research · 2026Article
- Interpreting bone age advancement in premature adrenarche remains challenging.Pediatric research · 2026Article
- A Maturation-Aware Machine Learning Framework for Screening the Nutritional Status of Adolescents.Nutrients · 2026Article
- Bone age, predicted adult height and HOMA-IR in children and adolescents with overweight and obesity: a single-centre cross-sectional study.BMJ paediatrics open · 2026Article
- Adrenal androgen mediates the association between obesity and accelerated skeletal maturation in children and adolescents.Frontiers in endocrinology · 2026Article
- Predicted Adult Height Remained Normal in Children With Premature Adrenarche Despite Advanced Bone Age.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Body composition in prepubertal children with idiopathic premature adrenarche: implications for cardiometabolic health.Pediatric research · 2025Observational
- Association of obesity and adrenal androgen levels with bone age progression in boys with premature adrenarche.Annals of pediatric endocrinology & metabolism · 2025Article
- Investigating insulin's role in regulating local aromatase in growth plate development.PloS one · 2025Article
- Correlation of bone age development with overweight and obesity in 23,305 children from Beijing.Endocrine · 2025Article
- Variant pubertal development in Prader-Willi syndrome: early and slow progression of pubarche with normal age at gonadarche.Frontiers in endocrinology · 2025Article
- Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes.European journal of endocrinology · 2024Article
- Association between sex hormones and bone age in boys aged 9-18 years from China.Journal of cellular and molecular medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Obesity and premature adrenarche (PA) are both associated with bone age (BA) advancement of unclear etiology, which may lead to earlier puberty, suboptimal final height and obesity in adulthood. Our objective was to understand the hormonal and anthropometric characteristics of BA advancement in a spectrum of prepubertal children with and without obesity and PA. In this cross-sectional study of 66 prepubertal children (35 PA, 31 control, 5-9 years), BMI z-score, hormonal values and response to an oral glucose tolerance test were the main outcome measures. Subjects were divided into tertiles by BA divided by chronological age (BA/CA), an index of BA advancement. Subjects in the top tertile for BA/CA had the highest dehydroepiandrosterone sulfate (DHEAS), free testosterone (%), hemoglobin A(1C), BMI z-score, and weight (P < 0.05). BMI z-score (r = 0.47), weight (r = 0.40), free testosterone (%) (r = 0.34), and DHEAS (r = 0.30) correlated with BA/CA (P < 0.02). Regression analysis showed greater BA/CA in PA compared to controls after controlling for weight (0.21 ± 0.56, P < 0.004). An exploratory stepwise regression model showed that weight, estradiol, and DHEAS were the strongest predictors of BA/CA accounting for 24% of its variance. Obesity was highly associated with BA advancement in this study of prepubertal children. In addition, children with PA had greater BA/CA at any given weight when compared to controls. These findings suggest a possible hormonal factor, which potentiates the effect of obesity on BA advancement in children with obesity and/or PA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.