ArticleJournal of perinatology : official journal of the California Perinatal Association2011
Echocardiographic measures of ventricular function and pulmonary artery size: prognostic markers of congenital diaphragmatic hernia?
Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Ventricular function in congenital diaphragmatic hernia: a systematic review and meta-analysis.European journal of pediatrics · 2022Pooled it
- Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Guideline
- Automated detection of neonatal pulmonary hypertension in echocardiograms with a deep learning model.Pediatric research · 2026Article
- Early post-operative hemodynamic recovery in infants with congenital diaphragmatic hernia.European journal of pediatrics · 2026Article
- Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia: a narrative review.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Early echocardiographic pulmonary artery measurements as prognostic indicators in left congenital diaphragmatic hernia.BMC pediatrics · 2023Article
- Longitudinal Trajectory of Ventricular Function and Pulmonary Hypertension in Congenital Diaphragmatic Hernia.The Journal of pediatrics · 2023Article
- Congenital Diaphragmatic Hernia: Perinatal Prognostic Factors and Short-Term Outcomes in a Single-Center Series.Children (Basel, Switzerland) · 2023Article
- The heart in congenital diaphragmatic hernia: Knowns, unknowns, and future priorities.Frontiers in pediatrics · 2022Review
- Management of Congenital Diaphragmatic Hernia (CDH): Role of Molecular Genetics.International journal of molecular sciences · 2021Review
- Early Left Ventricular Dysfunction and Severe Pulmonary Hypertension Predict Adverse Outcomes in "Low-Risk" Congenital Diaphragmatic Hernia.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020Article
- Cardiac Function Assessments in Left Bochdalek's Hernia: Clinical Relevance.Pediatric cardiology · 2018Article
- Clinical Utility of Echocardiography for Early and Late Pulmonary Hypertension in Preterm Infants: Relation with Bronchopulmonary Dysplasia.Journal of cardiovascular ultrasound · 2017Article
- Echocardiographic Evaluation of Hemodynamics in Neonates and Children.Frontiers in pediatrics · 2017Review
- Current Concepts in the Management of Congenital Diaphragmatic Hernia in Infants.The Indian journal of surgery · 2015Review
- Longitudinal systolic left ventricular function in preterm and term neonates: reference values of the mitral annular plane systolic excursion (MAPSE) and calculation of z-scores.Pediatric cardiology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare echocardiographic measures of biventricular function and pulmonary artery size in infants with congenital diaphragmatic hernia (CDH) and normal controls, and examine their correlation, if any, with outcomes in CDH. STUDY
designWe included consecutive neonates (<1 month old) with CDH and term controls without structural heart defects. Clinical and outcomes data were recorded and echocardiograms evaluated for right ventricular (RV) and left ventricular (LV) myocardial performance index (MPI), cardiac output index (CI) and McGoon index, among others. Statistical analyses (SPSS version 17, SPSS, Chicago, IL, USA) included between-group comparisons, using analysis of variance and χ(2)-test and binary regression, with significance set at P<0.05.
resultInfants with CDH (n=34) were comparable with controls (n=35) in their age, weight, gestational age and gender. CDH was left sided in 24 (70%) neonates. Extracorporeal membrane oxygenation (ECMO) was required in 15 (45%) neonates; 18 (53%) infants survived. MPIs, CI and eccentricity index in systole were significantly worse in the CDH group, compared with controls and among CDH infants who died, compared with survivors. Infants with CDH who died or needed ECMO had significantly impaired MPIs and CI than survivors. On regression analyses, LV CI and MPIs were independently associated with mortality.
conclusionInfants with CDH had significantly impaired ventricular function and pulmonary hypertension, compared with controls. In the CDH group, LV dysfunction was associated with death and adverse outcomes. Further studies incorporating echocardiographic indices as prognostic markers of CDH are warranted.
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Registered trials
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