ArticleInvestigative ophthalmology & visual science2011
Characterization of ocular tissues using microindentation and hertzian viscoelastic models.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Finite Element Analysis of Extraocular Muscle and Adipose-Dominant Pathogenesis in Thyroid Eye Disease With Clinical Implications.Translational vision science & technology · 2026Article
- Linear Viscoelasticity of Human Ocular Tissues During Tensile Stress Relaxation.Investigative ophthalmology & visual science · 2026Article
- Changes in the nonlinear and viscoelastic mechanical properties of the rat lamina cribrosa under chronic high intraocular pressure.Frontiers in bioengineering and biotechnology · 2026Article
- Microindentation reveals softening of the equatorial and anterior sclera during early myopia development in tree shrew eyes.Acta biomaterialia · 2025Article
- Finite Element Analysis of Ocular Impact Forces and Potential Complications in Pickleball-Related Eye Injuries.Bioengineering (Basel, Switzerland) · 2025Article
- Shear viscoelastic properties of human orbital fat.Journal of biomechanics · 2024Article
- Finite element method for estimation of applanation force and to study the influence of intraocular pressure of eye on tonometry.International ophthalmology · 2022Article
- 2021 update on thyroid-associated ophthalmopathy.Journal of endocrinological investigation · 2022Review
- Bilaminar Mechanics of the Human Optic Nerve Sheath.Current eye research · 2020Article
- HIF2A-LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy.Endocrinology · 2019Article
- Opto-mechanical characterization of sclera by polarization sensitive optical coherence tomography.Journal of biomechanics · 2018Article
- Quantitative characterization of viscoelastic behavior in tissue-mimicking phantoms and ex vivo animal tissues.PloS one · 2018Article
- Finite Element Biomechanics of Optic Nerve Sheath Traction in Adduction.Journal of biomechanical engineering · 2017Article
- Viscoelastic characterization of extraocular Z-myotomy.Investigative ophthalmology & visual science · 2014Article
- Atomic force microscopy determination of Young׳s modulus of bovine extra-ocular tendon fiber bundles.Journal of biomechanics · 2014Article
- An inverse method to determine the mechanical properties of the iris in vivo.Biomedical engineering online · 2014Article
- Biomechanics of superior oblique Z-tenotomy.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2013Article
- Empirical measurements of biomechanical anisotropy of the human vocal fold lamina propria.Biomechanics and modeling in mechanobiology · 2013Article
- Studies of scleral biomechanical behavior related to susceptibility for retinal ganglion cell loss in experimental mouse glaucoma.Investigative ophthalmology & visual science · 2013Article
- Determination of poisson ratio of bovine extraocular muscle by computed X-ray tomography.BioMed research international · 2013Article
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Authors and funding
11 authors.
Funding
Abstract
purposeThe authors applied a novel microindentation technique to characterize biomechanical properties of small ocular and orbital tissue specimens using the hertzian viscoelastic formulation, which defines material viscoelasticity in terms of the contact pressure required to maintain deformation by a harder body.
methodsThey used a hard spherical indenter having 100 nm displacement and 100 μg force precision to impose small deformations on fresh bovine sclera, iris, crystalline lens, kidney fat, orbital pulley tissue, and orbital fatty tissue; normal human orbital fat, eyelid fat, and dermal fat; and orbital fat associated with thyroid eye disease. For each tissue, stress relaxation testing was performed using a range of ramp displacements. Results for single displacements were used to build quantitative hertzian models that were, in turn, compared with behavior for other displacements. Findings in orbital tissues were correlated with quantitative histology.
resultsViscoelastic properties of small specimens of orbital and ocular tissues were reliably characterized over a wide range of rates and displacements by microindentation using the hertzian formulation. Bovine and human orbital fatty tissues exhibited highly similar elastic and viscous behaviors, but all other orbital tissues exhibited a wide range of biomechanical properties. Stiffness of fatty tissues tissue depended strongly on the connective tissue content.
conclusionsRelaxation testing by microindentation is a powerful method for characterization of time-dependent behaviors of a wide range of ocular and orbital tissues using small specimens, and provides data suitable to define finite element models of a wide range of tissue interactions.
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