ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011
Age-related skeletal muscle decline is similar in HIV-infected and uninfected individuals.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- A systematic review of sarcopenia prevalence and associated factors in people living with human immunodeficiency virus.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Sarcopenia in people living with the Human Immunodeficiency Virus: a systematic review and meta-analysis.European journal of clinical nutrition · 2020Pooled it
- Weight and lean body mass change with antiretroviral initiation and impact on bone mineral density.AIDS (London, England) · 2013Trial
- Body composition, soluble markers of inflammation, and bone mineral density in antiretroviral therapy-naive HIV-1-infected individuals.Journal of acquired immune deficiency syndromes (1999) · 2013Trial
- Assessment of Sarcopenia and Metabolic Abnormalities in HIV Patients Stable on Antiretroviral Therapy: A Cross-Sectional Analysis of an Indian Cohort.Journal of frailty, sarcopenia and falls · 2026Article
- Platelet Mitochondrial Function, Physical Performance, and Body Composition in Older People Living with HIV: A Preliminary Study.International journal of molecular sciences · 2026Article
- Factors associated with sarcopenia and exploratory thresholds for low muscle strength in people living with the human immunodeficiency virus.BMC infectious diseases · 2026Article
- Geriatric syndromes in women living with HIV.Current opinion in HIV and AIDS · 2026Review
- Randomized Clinical Trial of High Intensity Exercise in People with HIV: Effects on Muscle Composition and Inflammation.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Sarcopenic obesity and reduced BMD in young men living with HIV: body composition and sex steroids interplay.Journal of endocrinological investigation · 2024Observational
- The Risk of Malnutrition and Sarcopenia in Elderly People Living with HIV during the COVID-19 Pandemic.Nutrients · 2024Article
- Alcohol Impairs Bioenergetics and Differentiation Capacity of Myoblasts from Simian Immunodeficiency Virus-Infected Female Macaques.International journal of molecular sciences · 2024Article
- The use of non-invasive imaging modalities for the assessment of skeletal muscle quantity and quality in people with HIV: A narrative review.HIV medicine · 2023Review
- Sarcopenia in people living with HIV in Hong Kong: which definition correlates with health outcomes?Journal of the International AIDS Society · 2022Article
- Differences in Muscle Quantity and Quality by HIV Serostatus and Sex.The Journal of frailty & aging · 2022Article
- Efavirenz, atazanavir, and ritonavir disrupt sarcoplasmic reticulum CaAntiviral research · 2021Article
- Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot.The Journal of antimicrobial chemotherapy · 2019Article
- Lean mass declines consistently over 10 years in people living with HIV on antiretroviral therapy, with patterns differing by sex.Antiviral therapy · 2019Article
- High Prevalence of Sarcopenia in HIV-Infected Individuals.BioMed research international · 2018Article
- Geriatric syndromes: new frontiers in HIV and sarcopenia.AIDS (London, England) · 2017Review
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundSkeletal muscle (SM) mass decreases with advanced age and with disease in HIV infection. It is unknown whether age-related muscle loss is accelerated in the current era of antiretroviral therapy and which factors might contribute to muscle loss among HIV-infected adults. We hypothesized that muscle mass would be lower and decline faster in HIV-infected adults than in similar-aged controls.
methodsWhole-body (1)H-magnetic resonance imaging was used to quantify regional and total SM in 399 HIV-infected and 204 control men and women at baseline and 5 years later. Multivariable regression identified associated factors.
resultsAt baseline and Year 5, total SM was lower in HIV-infected than control men. HIV-infected women were similar to control women at both time points. After adjusting for demographics, lifestyle factors, and total adipose tissue, HIV infection was associated with lower Year 5 SM in men and higher SM in women compared with controls. Average overall 5-year change in total SM was small and age related, but rate of change was similar in HIV-infected and control men and women. CD4 count and efavirenz use in HIV-infected participants were associated with increasing SM, whereas age and stavudine use were associated with decreasing SM.
conclusionsMuscle mass was lower in HIV-infected men compared with controls, whereas HIV-infected women had slightly higher SM than control women after multivariable adjustment. We found evidence against substantially faster SM decline in HIV infected versus similar-aged controls. SM gain was associated with increasing CD4 count, whereas stavudine use may contribute to SM loss.
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