ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2011
Association between obesity history and hand grip strength in older adults--exploring the roles of inflammation and insulin resistance as mediating factors.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.
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Who cites it
61 citing papers in PubMed, 3 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- The impact of periodontitis on physical fitness: a systematic review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026Pooled it
- Five-factor model personality traits and grip strength: Meta-analysis of seven studies.Journal of psychosomatic research · 2022Pooled it
- Temporal Trends in the Handgrip Strength of 2,592,714 Adults from 14 Countries Between 1960 and 2017: A Systematic Analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Meal-based enhancement of protein quality and quantity during weight loss in obese older adults with mobility limitations: rationale and design for the MEASUR-UP trial.Contemporary clinical trials · 2015Trial
- Combined Measure of Hand Grip Strength and Body Mass Index for Predicting Excess Body Fat in a University Population in Kentucky, USA.Diagnostics (Basel, Switzerland) · 2026Article
- Serum chemerin levels and the risk of muscle health decline in geriatric population.Nutrition & metabolism · 2025Article
- Longitudinal association between body mass index and handgrip strength in community-dwelling older adults: a population-based nationwide cohort study.BMC geriatrics · 2025Article
- Anthropometric metabolic subtypes and health outcomes: A data-driven cluster analysis.Diabetes, obesity & metabolism · 2025Article
- Comparison of Postorthodontic Occlusal Force Distributions between Nonextraction and Extraction Treatment Approaches of Premolars for Orthodontic Treatment by Using T-Scan III System.European journal of dentistry · 2025Article
- Body mass index and trajectories of muscle strength and physical function over time in Mexican American older adults: Sex differences.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2025Article
- Hand Grip Strength Cut-Off Points as a Discriminator of Sarcopenia and Sarcopenic Obesity: Results from the ELSA-Brasil Cohort.Journal of cachexia, sarcopenia and muscle · 2025Article
- The relationship between early adulthood obesity and sarcopenic obesity among middle-aged and older adults in the United States.Frontiers in public health · 2025Article
- Handgrip Strength has Declined Among Adults, Particularly Males, from Shanghai Since 2000.Sports medicine - open · 2024Article
- Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults: Established and Emerging Treatments and Therapies.Diabetes & metabolism journal · 2023Review
- Chronic inflammation does not mediate the effect of adiposity on grip strength: results from a multivariable Mendelian randomization study.Scientific reports · 2023Article
- The Controversial Relationship between Body Mass Index and Handgrip Strength in the Elderly: An Overview.The Malaysian journal of medical sciences : MJMS · 2023Review
- Sarcopenic obesity definitions and their associations with physical frailty in older Brazilian adults: data from the SARCOS study.Archives of endocrinology and metabolism · 2023Article
- Relationship between Social Support, Sarcopenia, and Cognitive Impairment in Chinese Community-Dwelling Older Adults.The journal of nutrition, health & aging · 2023Article
- Field-Based Estimates of Muscle Quality Index Determine Timed-Up-and-Go Test Performance in Obese Older Women.Clinical interventions in aging · 2023Article
- The consumption of culinary preparations and ultra-processed food is associated with handgrip strength in teenagers.Nutrition journal · 2022Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundTo examine the association between obesity history and hand grip strength, and whether the association is partly explained by subclinical inflammation and insulin resistance.
methodsData are from 2,021 men and women aged 55 years and older participating in the representative population-based Health 2000 Survey in Finland. Body mass and body height, maximal hand grip strength, C-reactive protein, and insulin resistance based on homeostasis model assessment (HOMA-IR) were measured in a health examination. Recalled weight at 20, 30, 40, and 50 years of age were recorded to obtain a hierarchical classification of obesity history. Obesity was defined as body mass index ≥ 30 kg/m².
resultsEarlier onset of obesity was associated with lower hand grip strength (p < .001) after controlling for age, sex, education, smoking, alcohol use, physical activity, several chronic diseases, and current body weight. Based on adjusted logistic regression models, the odds (95% confidence interval) for very low relative hand grip strength were 2.76 (1.78-4.28) for currently obese, 5.57 (3.02-10.28) for obese since age of 50 years, 6.53 (2.98-14.30) for obese since age of 40 years, and 10.36 (3.55-30.24) for obese since age of 30 years compared with never obese participants. The associations remained highly significant even after adjusting for current C-reactive protein and HOMA-IR, but these variables had only minor role in explaining the association between obesity history and hand grip strength.
conclusionsLong-term exposure to obesity is associated with poor hand grip strength later in life. Maintaining healthy body weight throughout the life span may help to maintain adequate muscle strength in old age. Prospective studies with information on prior muscle strength are needed to examine in detail the causal association between obesity history and muscle strength.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.