Evidence map›Paper›PMID 21310240›Full record

ReviewMethods (San Diego, Calif.)2011

Imaging of nucleic acids with atomic force microscopy.

Yuri L Lyubchenko, Luda S Shlyakhtenko, Toshio Ando

Abstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Multiscale modeling primer: Focus on chromatin and epigenetics.The Journal of biological chemistry · 2026
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuri L LyubchenkoDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198-6025, USA. ylyubchenko@unmc.edu
Luda S Shlyakhtenko
Toshio Ando

Funding

LOCAL AND GLOBAL STRUCTURES OF SUPERCOILED DNAR01GM062235 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI LYUBCHENKO, YURI L · 2001 to 2007
$1.7M
NIGMS NIH HHS GM 62235NIGMS NIH HHS R01 GM062235
6 · The paper itself

Abstract

Atomic force microscopy (AFM) is a key tool of nanotechnology with great importance in applications to DNA nanotechnology and to the recently emerging field of RNA nanotechnology. Advances in the methodology of AFM now enable reliable and reproducible imaging of DNA of various structures, topologies, and DNA and RNA nanostructures. These advances are reviewed here with emphasis on methods utilizing modification of mica to prepare the surfaces enabling reliable and reproducible imaging of DNA and RNA nanostructures. Since the AFM technology for DNA is more mature, AFM imaging of DNA is introduced in this review to provide experience and background for the improvement of AFM imaging of RNA. Examples of imaging different structures of RNA and DNA are discussed and illustrated. Special attention is given to the potential use of AFM to image the dynamics of nucleic acids at the nanometer scale. As such, we review recent advances with the use of time-lapse AFM.

Indexed as

Nucleic Acid ConformationAluminum SilicatesDNADNA, CruciformMicroscopy, Atomic ForcePropylaminesRNASilanesSurface PropertiesTime-Lapse ImagingAluminum Silicatesamino-propyl-triethoxysilaneDNADNA, CruciformmicaPropylaminesRNASilanes

Identifiers

PMID21310240
PMCPMC3114274

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.