ArticleInternational journal for parasitology2011
Construction of a genetic map for Theileria parva: identification of hotspots of recombination.
Article in International journal for parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Genetic Diversity of Theileria parva and Anaplasma spp. Isolated From Ticks Collected From Kiambu County, Kenya.BioMed research international · 2026Article
- Article
- Molecular detection and characterization of a novel Theileria genotype in Dama GazelleInternational journal for parasitology. Parasites and wildlife · 2023Article
- Genetic association of toxin production in the dinoflagellateMicrobial genomics · 2022Article
- Development of a Potential Yeast-Based Vaccine Platform forFrontiers in immunology · 2021Article
- Antigenic Diversity inFrontiers in genetics · 2021Article
- Variant analysis of the sporozoite surface antigen gene reveals that asymptomatic cattle from wildlife-livestock interface areas in northern Tanzania harbour buffalo-derived T. parva.Parasitology research · 2020Article
- Theileria parva: a parasite of African buffalo, which has adapted to infect and undergo transmission in cattle.International journal for parasitology · 2020Review
- Ancient diversity and geographical sub-structuring in African buffalo Theileria parva populations revealed through metagenetic analysis of antigen-encoding loci.International journal for parasitology · 2018Article
- Genomics of apicomplexan parasites.Critical reviews in biochemistry and molecular biology · 2017Review
- Limited genetic and antigenic diversity within parasite isolates used in a live vaccine against Theileria parva.International journal for parasitology · 2016Article
- Identification of novel Theileria genotypes from Grant's gazelle.International journal for parasitology. Parasites and wildlife · 2015Article
- Development of Gossypium anomalum-derived microsatellite markers and their use for genome-wide identification of recombination between the G. anomalum and G. hirsutum genomes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2015Article
- Whole-genome sequencing of Theileria parva strains provides insight into parasite migration and diversification in the African continent.DNA research : an international journal for rapid publication of reports on genes and genomes · 2013Article
- Genetic mapping and coccidial parasites: past achievements and future prospects.Journal of biosciences · 2012Review
- High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing.BMC genomics · 2012Article
- A sequence-anchored linkage map of the plant-parasitic nematode Meloidogyne hapla reveals exceptionally high genome-wide recombination.G3 (Bethesda, Md.) · 2012Article
- Analysis of malaria parasite phenotypes using experimental genetic crosses of Plasmodium falciparum.International journal for parasitology · 2012Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The tick-borne protozoan parasite Theileria parva is the causal agent of East Coast Fever (ECF), a severe lymphoproliferative disease of cattle in eastern, central and southern Africa. The life cycle of T. parva is predominantly haploid, with a brief diploid stage occurring in the tick vector that involves meiotic recombination. Resolved genetic studies of T. parva are currently constrained by the lack of a genome-wide high-definition genetic map of the parasite. We undertook a genetic cross of two cloned isolates of T. parva to construct such a map from 35 recombinant progeny, using a genome-wide panel of 79 variable number of tandem repeat markers. Progeny were established by in vitro cloning of cattle lymphocytes after infection with sporozoites prepared from Rhipicephalus appendiculatus ticks fed on a calf undergoing a dual infection with the two clonal parental stocks. The genetic map was determined by assigning individual markers to the four chromosome genome, whose physical length is approximately 8309 kilobasepairs (Kb). Segregation analysis of the markers among the progeny revealed a total genetic size of 1683.8 centiMorgans (cM), covering a physical distance of 7737.62 Kb (∼93% of the genome). The average genome-wide recombination rate observed for T. parva was relatively high, at 0.22 cM Kb(-1) per meiotic generation. Recombination hot-spots and cold-spots were identified for each of the chromosomes. A panel of 27 loci encoding determinants previously identified as immunorelevant or likely to be under selection were positioned on the linkage map. We believe this to be the first genetic linkage map for T. parva. This resource, with the availability of the genome sequence of T. parva, will promote improved understanding of the pathogen by facilitating the use of genetic analysis for identification of loci responsible for variable phenotypic traits exhibited by individual parasite stocks.
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