ReviewJournal of child psychology and psychiatry, and allied disciplines2011
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.
Review in Journal of child psychology and psychiatry, and allied disciplines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Genome-Wide DNA Methylation Patterns in Children Exposed to Nonpharmacologically Treated Prenatal Depressive Symptoms: Results From 2 Independent Cohorts.Epigenetics insights · 2020Article
- TheJournal of clinical medicine · 2019Review
- Decreased Expression of Synaptophysin 1 (SYP1 Major Synaptic Vesicle Protein p38) and Contactin 6 (CNTN6/NB3) in the Cerebellar Vermis of reln Haplodeficient Mice.Cellular and molecular neurobiology · 2019Article
- Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.Molecular psychiatry · 2017Review
- Increased PKC activity and altered GSK3β/NMDAR function drive behavior cycling in HINT1-deficient mice: bipolarity or opposing forces.Scientific reports · 2017Article
- Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish.Disease models & mechanisms · 2015Review
- Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas.Autism research : official journal of the International Society for Autism Research · 2014Article
- iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls.Trends in molecular medicine · 2014Review
- Oxidation of polychlorinated biphenyls by liver tissue slices from phenobarbital-pretreated mice is congener-specific and atropselective.Chemical research in toxicology · 2013Article
- Severe cross-modal object recognition deficits in rats treated sub-chronically with NMDA receptor antagonists are reversed by systemic nicotine: implications for abnormal multisensory integration in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Cellular reprogramming: a novel tool for investigating autism spectrum disorders.Trends in molecular medicine · 2012Review
- Modeling human neurodegenerative diseases in transgenic systems.Human genetics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Childhood-onset psychiatric disorders, such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), mood disorders, obsessive compulsive spectrum disorders (OCSD), and schizophrenia (SZ), affect many school-age children, leading to a lower quality of life, including difficulties in school and personal relationships that persist into adulthood. Currently, the causes of these psychiatric disorders are poorly understood, resulting in difficulty diagnosing affected children, and insufficient treatment options. Family and twin studies implicate a genetic contribution for ADHD, ASD, mood disorders, OCSD, and SZ. Identification of candidate genes and chromosomal regions associated with a particular disorder provide targets for directed research, and understanding how these genes influence the disease state will provide valuable insights for improving the diagnosis and treatment of children with psychiatric disorders. Transgenic mouse models are one important approach in the study of human diseases, allowing for the use of a variety of experimental approaches to dissect the contribution of a specific chromosomal or genetic abnormality in human disorders. While it is impossible to model an entire psychiatric disorder in a single mouse model, these models can be extremely valuable in dissecting out the specific role of a gene, pathway, neuron subtype, or brain region in a particular abnormal behavior. In this review we discuss existing transgenic mouse models for childhood-onset psychiatric disorders. We compare the strength and weakness of various transgenic mouse models proposed for each of the common childhood-onset psychiatric disorders, and discuss future directions for the study of these disorders using cutting-edge genetic tools.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.