ReviewJournal of child psychology and psychiatry, and allied disciplines2011
Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention?
Review in Journal of child psychology and psychiatry, and allied disciplines, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Rehabilitation in Pediatric Patients with Acute and Subacute Acquired Brain Injury: A Scoping Review on Non-Pharmacological Interventions.Journal of clinical medicine · 2026Review
- Development of Posterior Medial Frontal Cortex Function in Pediatric Obsessive-Compulsive Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2018Article
- Dosing and Monitoring: Children and Adolescents.Psychopharmacology bulletin · 2018Review
- Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors.Neuropsychiatric disease and treatment · 2018Article
- Sensitive periods of substance abuse: Early risk for the transition to dependence.Developmental cognitive neuroscience · 2017Review
- Trends in Atypical Antipsychotics Prescribed to Children Six Years of Age or Less on Medicaid in Kentucky.Journal of child and adolescent psychopharmacology · 2015Article
- Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens.Schizophrenia research · 2015Article
- A groundwork for allostatic neuro-education.Frontiers in psychology · 2015Article
- Reducing substance use during adolescence: a translational framework for prevention.Psychopharmacology · 2014Review
- Chronic fluoxetine treatment changes S100B expression during postnatal rat brain development.Journal of child and adolescent psychopharmacology · 2013Article
- Olanzapine treatment of adolescent rats alters adult reward behaviour and nucleus accumbens function.The international journal of neuropsychopharmacology · 2013Article
- Updates on treatment of attention-deficit/hyperactivity disorder: facts, comments, and ethical considerations.Current treatment options in neurology · 2012Article
- Experience and the developing prefrontal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Drugs for kids: good or bad?Journal of psychiatry & neuroscience : JPN · 2012Article
- Preventive interventions for ADHD: a neurodevelopmental perspective.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- The science of brain and biological development: implications for mental health research, practice and policy.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2011Article
- Effects of Stimulants and SSRIs on Brain Function in Children: Emerging Clues from fMRI Studies.Child & adolescent psychopharmacology news · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Our aim is to present a working model that may serve as a valuable heuristic to predict enduring effects of drugs when administered during development. Our primary tenet is that a greater understanding of neurodevelopment can lead to improved treatment that intervenes early in the progression of a given disorder and prevents symptoms from manifesting. The immature brain undergoes significant changes during the transitions between childhood, adolescence, and adulthood. Such changes in innervation, neurotransmitter levels, and their respective signaling mechanisms have profound and observable changes on typical behavior, but also increase vulnerability to psychiatric disorders when the maturational process goes awry. Given the remarkable plasticity of the immature brain to adapt to its external milieu, preventive interventions may be possible. We intend for this review to initiate a discussion of how currently used psychotropic agents can influence brain development. Drug exposure during sensitive periods may have beneficial long-term effects, but harmful delayed consequences may be possible as well. Regardless of the outcome, this information needs to be used to improve or develop alternative approaches for the treatment of childhood disorders. With this framework in mind, we present what is known about the effects of stimulants, antidepressants, and antipsychotics on brain maturation (including animal studies that use more clinically-relevant dosing paradigms or relevant animal models). We endeavor to provocatively set the stage for altering treatment approaches for improving mental health in non-adult populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.