Evidence map›Paper›PMID 21309696›Full record

Trial reportJournal of child and adolescent psychopharmacology2011

Safety and efficacy of donepezil in children and adolescents with autism: neuropsychological measures.

Benjamin L Handen, Cynthia R Johnson, Sarah McAuliffe-Bellin, Patricia Jo Murray, Antonio Y Hardan

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of child and adolescent psychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  12. Acetylcholinesterase inhibitors for autistic spectrum disorders.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Benjamin L HandenDepartment of Psychiatry, School of Medicine, University of Pittsburgh , Pittsburgh, PA 15203, USA. handenbl@upmc.edu
Cynthia R Johnson
Sarah McAuliffe-Bellin
Patricia Jo Murray
Antonio Y Hardan
Psychiatric Medical Center · AMChildren's Hospital of Pittsburgh · USStanford University · USUniversity of Pittsburgh · US

Funding

Donepezil HCL: Treating Cognitive Deficit in AutismR21MH064941 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDEN, BENJAMIN L · 2001 to 2003
$450k
NIMH NIH HHS 5R21 MH64941-03NIMH NIH HHS R21 MH064941
6 · The paper itself

Abstract

objectiveThere has been recent interest in the use of cognitive enhancing drugs, such as cholinesterase inhibitors, as a possible treatment for executive functioning (EF) deficits in autism spectrum disorder (ASD). The goal of this study was to assess the tolerability, safety, and efficacy of donepezil on EF in a sample of children and adolescents with ASD.

methodThirty-four children and adolescents with ASD (age range 8-17 years; IQ >75) were enrolled in a 10-week, double-blind, placebo-controlled trial of donepezil (doses of 5 and 10 mg), followed by a 10-week open label trial for placebo nonresponders.

resultsThe effect of donepezil treatment on EF was examined. Despite improvement on a number of EF measures, no statistically significant between-group differences were found (with gains observed for both the placebo and donepezil groups).

conclusionsThe results suggest that short-term treatment with donepezil may have limited impact on cognitive functioning in ASD. Future controlled trials may need to consider a longer treatment period to detect significant gains on EF measures.

Indexed as

AdolescentAutistic DisorderChildCholinesterase InhibitorsDonepezilDose-Response Relationship, DrugDouble-Blind MethodExecutive FunctionFemaleHumansIndansMaleNeuropsychological TestsPiperidinesCholinesterase InhibitorsDonepezilIndansPiperidines

Identifiers

PMID21309696
PMCPMC3037196
OpenAlexW2004511233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.