Evidence map›Paper›PMID 21309071›Full record

ReviewGenesis (New York, N.Y. : 2000)2011

Mouse resources for craniofacial research.

Stephen A Murray

Abstract readReview
In one paragraph

Review in Genesis (New York, N.Y. : 2000), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Craniofacial developmental biology in the single-cell era.Development (Cambridge, England) · 2023
    Review
  3. Review
  4. Article
  5. Article
  6. Establishing biomechanical mechanisms in mouse models: practical guidelines for systematically evaluating phenotypic changes in the diaphyses of long bones.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015
    Review
  7. Review
  8. Article
  9. Beyond knockouts: cre resources for conditional mutagenesis.Mammalian genome : official journal of the International Mammalian Genome Society · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Stephen A MurrayThe Jackson Laboratory, Bar Harbor, Maine, USA. steve.murray@jax.org

Funding

Technology Project: Genetic Tools and Resources for Orofacial Clefting ResearchU01DE020052 · NIDCR · JACKSON LABORATORY · PI MURRAY, STEPHEN A · 2009 to 2013
$3.2M
Enhancing the Utility of Cre Driver LinesR21RR026117 · NCRR · JACKSON LABORATORY · PI MURRAY, STEPHEN A · 2009 to 2010
$494k
Genetic Characterization of a Novel Model of Cleft PalateR03DE019451 · NIDCR · JACKSON LABORATORY · PI MURRAY, STEPHEN A · 2009 to 2010
$260k
NCRR NIH HHS R21 RR026117NCRR NIH HHS RR026117NIDCR NIH HHS DE019451NIDCR NIH HHS DE020052NIDCR NIH HHS R03 DE019451NIDCR NIH HHS U01 DE020052
6 · The paper itself

Abstract

The mouse, as a genetically defined and easily manipulated model organism, has played a critical role in unraveling the mechanisms of craniofacial development and dysmorphology. While numerous gene knockout strains that display craniofacial abnormalities and essential recombinase tool strains with craniofacial-specific expression have been generated, many are absent from public repositories. Large-scale, international resource-generating initiatives promise to address this concern, providing a comprehensive set of targeted mutations and a suite of new Cre driver strains. In addition, panels of genetically defined strains provide tools to dissect the multigenic, complex nature of craniofacial development, adding to the foundation of information gained from single gene studies. Continued progress will require awareness and access to these essential mouse resources. In this review, current mouse resources, large-scale efforts, and potential future directions will be outlined and discussed.

Indexed as

Databases, FactualModels, AnimalPhenotypeAnimalsCraniofacial AbnormalitiesIntegrasesInternational CooperationInternetMaxillofacial DevelopmentMiceMice, Mutant StrainsMutationSkullCre recombinaseIntegrases

Identifiers

PMID21309071
PMCPMC3610317

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.